Anesthetic effects of isoflurane and the molecular mechanism underlying isoflurane‑inhibited aggressiveness of hepatic carcinoma

Molecular Medicine Reports
Jing HuQingguo Li

Abstract

Anesthesia is produced by drugs or other methods, and refers to the attenuation of pain via reversible suppression of neuronal transmission in the central and peripheral nervous systems, during surgery. Clinical investigations have indicated that the anesthetic action of isoflurane is efficient to alleviate pain during tumor resection clinical trials. In addition, it has been reported that isoflurane can induce caspase‑3 activation and is associated with apoptosis of tumor cells. The present study investigated the anesthetic effects and molecular mechanisms underlying isoflurane‑induced apoptosis in patients with hepatic carcinoma. Furthermore, the pain of patients with hepatic carcinoma was evaluated during the perioperative period according to the pain index. The apoptotic rate of hepatic carcinoma cells was analyzed in tumor tissues using TUNEL assay. The expression levels of apoptosis‑associated proteins were detected in liver cancer cells following anesthesia in patients. Phosphoinositide 3‑kinase/protein kinase B (PI3K/AKT) and nuclear factor (NF)‑κB signaling pathways were also analyzed in liver cancer cells following treatment with isoflurane. The results demonstrated that isoflurane inhibited growth and decreased viabi...Continue Reading

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Citations

Mar 19, 2020·Cancer Management and Research·Yichi XuXueqiong Zhu
Sep 15, 2020·Cancer Management and Research·Xiaoqing FanRuiting Wang
Mar 16, 2021·Frontiers in Oncology·Jiaqiang WangShaoqiang Huang
Feb 18, 2021·Korean journal of anesthesiology·Azeem AlamDaqing Ma
Jul 3, 2021·Current Issues in Molecular Biology·Crina E TironIoana Grigoras

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Methods Mentioned

BETA
ELISA
protein assay
light microscopy

Software Mentioned

GraphPad
GraphPad Prism

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