Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats.

Journal of the American Society of Nephrology : JASN
K M LochheadR A Zager

Abstract

Isoflurane, the most widely used inhalational anesthetic, releases inorganic fluoride during its metabolism by the cytochrome P450 system. Recent experimental data indicate that when cultured proximal tubular cells are exposed to inorganic fluoride, they become relatively resistant to myoglobin- and ATP depletion-mediated attack. The present study was undertaken to assess whether isoflurane anesthesia might confer in vivo cytoprotection, possibly by causing renal tubular inorganic fluoride exposure, thereby mitigating a combined myoglobin/ATP depletion model of acute renal failure (glycerol-induced ARF). Rats were injected with hypertonic glycerol (50%; 9 ml/kg, intramuscularly) while undergoing 4 h of isoflurane anesthesia. Glycerol-injected rats anesthetized with a virtually nondefluorinated inhalational anesthetic (desflurane) or with a nonfluorinated anesthetic (pentobarbital) served as controls. The severity of ARF was assessed 24 h later (blood urea nitrogen, plasma creatinine [Cr], and renal histology). Anesthetic effects on extrarenal injury (plasma creatine phosphokinase, lactate dehydrogenase, and hematocrit levels), acute intrarenal heme loading (cast formation), and BP during the initiation phase of renal injury (0 ...Continue Reading

Citations

Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Kevin R KozakGerald Schulman
Aug 5, 1998·Kidney International·K M Lochhead, R A Zager
Oct 19, 2007·American Journal of Physiology. Renal Physiology·Richard A ZagerKarol Bomsztyk
Jul 11, 2009·The Journal of Trauma·Yi-Maun SubeqBang-Gee Hsu

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