Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia.

Anesthesia and Analgesia
Liya Yang, James M Sonner

Abstract

Inhaled anesthetics are interfacially active, concentrating at interfaces such as the protein/water or bilayer/water interfaces. We tested the hypothesis that interfacial activity was a sufficient condition for anesthetic-like modulation of receptor function by applying surfactants to gamma-aminobutyric acid type A (GABA(A)), glycine, and N-methyl-d-aspartate (NMDA) receptors. We defined anesthetic-like modulation as an increase in currents through native channels that isoflurane and ethanol increased currents through, and a decrease in currents through channels that isoflurane and ethanol decreased currents through. We also tested the null hypothesis that there would be no difference in modulation of channel currents by surfactants in receptors with point mutations that diminished their response to isoflurane and ethanol compared to the native version of these receptors. The effect of seven surfactants with different head group charges (anionic, cationic, zwitterionic, and uncharged) and tail lengths (8 carbons and 12 carbons) on homomeric wild type alpha1 and mutant alpha(1) (S267I) glycine receptors, wild type alpha(1)beta(2)gamma(2s) and mutant alpha(1)(S270I)beta(2)gamma(2s) GABA(A) receptors, and wild type NR1/NR2A and mu...Continue Reading

References

Dec 1, 1994·Anesthesia and Analgesia·D D KoblinP Ionescu
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May 22, 2007·Anesthesia and Analgesia·Robert J BrosnanJames M Sonner
Aug 25, 2007·Anesthesia and Analgesia·Liya YangJames M Sonner

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Citations

Feb 26, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven MennerickCharles F Zorumski
Feb 19, 2014·Medical Gas Research·Derek S NowrangiJohn H Zhang
Mar 5, 2013·Annual Review of Biophysics·James M Sonner, Robert S Cantor
Jul 28, 2016·Biochimica Et Biophysica Acta·Francisco Javier Sierra-ValdezIlse Delint-Ramirez
Jan 15, 2013·Journal of the American Chemical Society·Günther H PetersPeter Westh
Oct 12, 2016·Scientific Reports·I KolbC R Forest
Aug 21, 2008·Anesthesia and Analgesia·Edmond I EgerJames M Sonner
Aug 21, 2008·Anesthesia and Analgesia·James M Sonner
Jul 10, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P L R AndrewsJ F Nash
Jan 24, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Tienyi T HsuGerald G Fuller

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