PMID: 15232804Jul 3, 2004Paper

Anesthetic myocardial protection with sevoflurane

Journal of Cardiothoracic and Vascular Anesthesia
Nader D NaderAnthony L Panos

Abstract

To examine the role of sevoflurane in myocardial protection in patients undergoing coronary artery bypass graft (CABG) surgery. Prospective, randomized, controlled, double-blinded study. Veterans Administration Medical Center (VAMC), Buffalo, New York. Twenty-one patients undergoing CABG were included in the study. Eleven patients were randomized to receive sevoflurane, and 10 patients served as controls. Total intravenous anesthesia was provided for both study and control groups by infusion of propofol, fentanyl, and midazolam. Sevoflurane 2% was added to the cardioplegia solution in the experimental group. Neutrophil beta-integrins (CD11b/CD18), tumor necrosis factor alpha (TNF-alpha), and interleukin (IL)-6 were measured as indicators of the inflammatory response to myocardial ischemia-reperfusion injury. Blood samples were obtained from the aorta and coronary sinus before (T1) and immediately after cardiopulmonary bypass (CPB) (T2) and, in addition, from a peripheral artery 6 hours (T3) after CPB. Myocardial function was determined in all patients at each time point. Left ventricular stroke work index (LVSWI) was calculated as an estimation of left ventricular function. Left ventricular regional wall motion abnormality (RWM...Continue Reading

References

May 11, 1992·The Journal of Thoracic and Cardiovascular Surgery·H KawataJ E Mayer
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·N DanaM A Arnaout
Jun 17, 1994·Annals of the New York Academy of Sciences·G L KukielkaM L Entman
Sep 1, 1995·Journal of Molecular and Cellular Cardiology·Y SeinoK Shimada
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
Nov 15, 1997·Journal of the American College of Cardiology·J GurevitchR Mohr
Feb 17, 1999·Journal of Molecular and Cellular Cardiology·N G FrangogiannisM L Entman

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Citations

Jun 9, 2009·British Journal of Anaesthesia·J FrässdorfW Schlack
Aug 7, 2013·Medical Gas Research·Franziska E Blum, Zhiyi Zuo
Sep 19, 2007·Expert Opinion on Emerging Drugs·Eric R Gross, Garrett J Gross
Apr 14, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Eun Jung ChoSung Bo Sim
Jul 30, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniAntonio Colombo
May 23, 2008·Best Practice & Research. Clinical Anaesthesiology·Yon Hee Shim, Judy R Kersten
Aug 7, 2007·Journal of Cardiothoracic and Vascular Anesthesia·Giovanni LandoniGiorgio Torri
Aug 18, 2005·Seminars in Thoracic and Cardiovascular Surgery·Hratch KarmanoukianNader D Nader
Oct 24, 2007·British Journal of Pharmacology·M-S SuleimanG D Angelini
Jan 15, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Vincent Piriou, Pascal Chiari
Aug 4, 2006·Journal of Cardiothoracic and Vascular Anesthesia·Takae KawamuraKatsuya Inada
Feb 21, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·C BaufretonF Pinaud
Apr 14, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·P ChiariV Piriou
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·Martin SchläpferRichard D Minshall
Jun 11, 2015·Best Practice & Research. Clinical Anaesthesiology·Julie L Huffmyer, Danja S Groves
Jun 11, 2015·Best Practice & Research. Clinical Anaesthesiology·Stefan De Hert, Anneliese Moerman
Jul 6, 2014·British Journal of Anaesthesia·B Müller-EdenbornB Beck-Schimmer
Aug 4, 2016·Acta Cirúrgica Brasileira·Christiane D'Oliveira MarquesYara Marcondes Machado Castiglia
Oct 24, 2009·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Yun-Tai Yao, Li-Huan Li
Jun 3, 2008·Asian Cardiovascular & Thoracic Annals·Suraphong LorsomradeeStefan G De Hert
Aug 9, 2011·Journal of Cardiovascular Pharmacology and Therapeutics·Robert M Mentzer
Jul 2, 2011·Seminars in Cardiothoracic and Vascular Anesthesia·Mehrdad AsgeriNader D Nader
May 17, 2006·Seminars in Cardiothoracic and Vascular Anesthesia·Stefan G De Hert
Jan 20, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Assad HaneyaYork Zausig
Sep 9, 2006·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chun Hua Yu, W Scott Beattie
Aug 1, 2009·European Journal of Anaesthesiology·Stefan G De HertWolfgang S Schlack
Mar 26, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ji-Hong XuYi-Nan Zhang

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