PMID: 8141455Mar 1, 1994Paper

Anesthetic potency is not altered after hypothermic spinal cord transection in rats

Anesthesiology
I J Rampil

Abstract

In essence, the clinical goal of general anesthesia is to produce a state of unresponsiveness and amnesia. These endpoints are commonly achieved with drugs like isoflurane, but the sites and mechanisms by which these specific endpoints are achieved remain unknown. Blocking the somatic motor response to painful stimuli is widely used as an indicator of anesthetic adequacy, and the concentration of anesthetic agent (minimum alveolar concentration [MAC]) required to achieve this unresponsiveness is the benchmark of anesthetic potency. Recent work has demonstrated that precollicular decerebration does not alter MAC in rats, suggesting that the forebrain is not a major site of action of isoflurane in blocking motor responses. The brain stem contains systems that modulate pain processing in the spinal cord. The current study was undertaken to assess the relative roles of the brain stem and spinal cord as sites of anesthetic action in blocking somatic responsiveness. In seven rats, anesthesia was induced and maintained with isoflurane in oxygen. MAC was determined by observing the response to tail clamp and fore- and hind limb toe pinch at three times: after intubation, after cervical laminectomy, and after staged hypothermic spinal c...Continue Reading

Citations

Aug 12, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F Antognini, X W Wang
Dec 7, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masahiro IrifuneMichio Kawahara
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Jan 1, 1997·Medical Hypotheses·J F Antognini
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