PMID: 8141455Mar 1, 1994Paper

Anesthetic potency is not altered after hypothermic spinal cord transection in rats

I J Rampil


In essence, the clinical goal of general anesthesia is to produce a state of unresponsiveness and amnesia. These endpoints are commonly achieved with drugs like isoflurane, but the sites and mechanisms by which these specific endpoints are achieved remain unknown. Blocking the somatic motor response to painful stimuli is widely used as an indicator of anesthetic adequacy, and the concentration of anesthetic agent (minimum alveolar concentration [MAC]) required to achieve this unresponsiveness is the benchmark of anesthetic potency. Recent work has demonstrated that precollicular decerebration does not alter MAC in rats, suggesting that the forebrain is not a major site of action of isoflurane in blocking motor responses. The brain stem contains systems that modulate pain processing in the spinal cord. The current study was undertaken to assess the relative roles of the brain stem and spinal cord as sites of anesthetic action in blocking somatic responsiveness. In seven rats, anesthesia was induced and maintained with isoflurane in oxygen. MAC was determined by observing the response to tail clamp and fore- and hind limb toe pinch at three times: after intubation, after cervical laminectomy, and after staged hypothermic spinal c...Continue Reading


Aug 12, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F Antognini, X W Wang
Dec 7, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Masahiro IrifuneMichio Kawahara
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F AntogniniE Carstens
May 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P S Glass
May 29, 2007·Der Anaesthesist·S KreuerT Bouillon
Apr 27, 2007·Journal of Anesthesia·Yumiko Ishizawa
May 29, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Peter S A Glass
May 26, 2005·European Journal of Pharmacology·Sachar LambertUwe Rudolph
Jan 1, 1997·Medical Hypotheses·J F Antognini
Feb 27, 1999·Toxicology Letters·B W Urban, P Friederich
Feb 27, 1999·Toxicology Letters·J F Antognini, E Carstens
Jun 28, 2002·British Journal of Pharmacology·Gong Cheng, Joan J Kendig
Oct 25, 2003·Anesthesiology·Anupama WadhwaDaniel I Sessler
Jul 28, 2004·Anesthesiology·Edwin B LiemDaniel I Sessler
Jun 6, 2009·European Journal of Anaesthesiology·Andrea Kopp LugliChristoph H Kindler
Oct 1, 1996·Acta Anaesthesiologica Scandinavica·T Heier, P A Steen
Jan 29, 2005·Acta Anaesthesiologica Scandinavica·A Holmström, J Akeson
Jan 25, 2005·Veterinary Anaesthesia and Analgesia·Louise ClarkMargo E Chase-Topping
Nov 29, 2008·Molecular Pharmacology·Peihan OrestesSlobodan M Todorovic
Feb 1, 1996·Anesthesia and Analgesia·L KandelE I Eger
Jul 1, 1996·Anesthesia and Analgesia·J M Garfield, C Bukusoglu
Mar 12, 1998·Anesthesia and Analgesia·J SonnerE I Eger
Mar 11, 1999·Anesthesia and Analgesia·J F AntogniniV Buzin
May 29, 2002·Anesthesia and Analgesia·Shirley M E WongJoan J Kendig
Dec 31, 2002·Anesthesia and Analgesia·Yi ZhangJames M Sonner
Dec 31, 2002·Anesthesia and Analgesia·Caroline StabernackEdmond I Eger

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