Aneuploidization under segmental allotetraploidy in rice and its phenotypic manifestation

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Ying WuBao Liu

Abstract

We report a repertoire of diverse aneuploids harbored by a newly synthesized segmental allotetraploid rice population with fully sequenced sub-genomes and demonstrate their retention features and phenotypic consequences. Aneuploidy, defined as unequal numbers of different chromosomes, is a large-effect genetic variant and may produce diverse cellular and organismal phenotypes. Polyploids are more permissive to chromosomal content imbalance than their diploid and haploid counterparts, and therefore, may enable more in-depth investigation of the phenotypic consequences of aneuploidy. Based on whole-genome resequencing, we identify that ca. 40% of the 312 selfed individual plants sampled from an early generation rice segmental allotetraploid population are constitutive aneuploids harboring 55 distinct aneuploid karyotypes. We document that gain of a chromosome is more prevalent than loss of a chromosome, and the 12 rice chromosomes have distinct tendencies to be in an aneuploid state. These properties of aneuploidy are constrained by multiple factors including the number of genes residing on the chromosome and predicted functional connectivity with other chromosomes. Two broad categories of aneuploidy-associated phenotypes are rec...Continue Reading

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Citations

Nov 8, 2018·Molecular Biology and Evolution·Franc-Christophe BaurensAngélique D'Hont
May 18, 2019·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhibin ZhangLei Gong
Jul 23, 2019·Genome Génome / Conseil National De Recherches Canada·Kishor KumarKuldeep Singh
Mar 7, 2021·Plants·Rongrong ChenDetian Cai

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Datasets Mentioned

BETA
PRJNA433716

Methods Mentioned

BETA
Rice Genome Sequencing

Software Mentioned

R
BWA
SAMtools
FarmCPU
Perl
FarmCPU ( Circulating Probability Unification )

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