Aneuploidy, an early event in mouse skin tumor development

Carcinogenesis
Claudio J ContiT J Slaga

Abstract

It has been suggested that chromosomal alterations can play a role in mouse skin carcinogenesis. These changes have been proposed as a possible mechanism of action of tumor promoters and they have also been related to the conversion of benign papillomas to carcinomas. However, direct evidence showing the chromosomal constitution of these tumors has not been previously described. Here we show the presence of aneuploid cells in very early papillomas and the eventual displacement of the diploid stem line by aneuploid clones at later stages. Squamous cell carcinomas (SCC) induced by the same protocol were highly aneuploid. These results suggest that genomic imbalance produced by aneuploidy may be related to the malignant conversion of the benign papillomas.

Citations

Oct 3, 2000·Cell Motility and the Cytoskeleton·P Duesberg, D Rasnick
Jan 1, 1988·Archives of Dermatological Research·F OtsukaY Ishibashi
Aug 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M E KaighnU Saffiotti
Dec 1, 1987·Mutation Research·J M Parry, E M Parry
Jan 1, 1992·Pharmacology & Therapeutics·J DiGiovanni
Jan 1, 1989·Free Radical Biology & Medicine·J P Perchellet, E M Perchellet
Jun 27, 2000·Cancer Genetics and Cytogenetics·P DuesbergR Hehlmann
Jan 1, 1992·Geriatric Nursing·J KellisonM Slusser
May 20, 1998·Mutation Research·M J AardemaR D Taalman
Aug 29, 2009·Nature Protocols·Erika L AbelJohn DiGiovanni
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·C M AldazT J Slaga
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A B BianchiC J Conti
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A B BianchiC J Conti
Dec 1, 1990·Journal of Cutaneous Pathology·T S WinokurP H Duray
Dec 1, 1987·Environmental Health Perspectives·J C Barrett, R W Wiseman
Apr 1, 1993·Environmental Health Perspectives·J C Barrett
Oct 1, 1995·Environmental Health Perspectives·L A Jones, R A Hajek
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·A GlickS H Yuspa
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·M HanausekJ U Gutterman
Aug 30, 2011·Trends in Genetics : TIG·Jason M Sheltzer, Angelika Amon
Jul 14, 2010·Cancer Genetics and Cytogenetics·Andreas KleinPeter Duesberg
Jun 2, 2004·Molecular Carcinogenesis·Laura A ChristensenKaren M Vasquez
Jun 28, 2005·International Journal of Cancer. Journal International Du Cancer·Mukul DasSubhash K Khanna
May 10, 2006·Molecular Carcinogenesis·Manoj K Pandey, Mukul Das
Jul 22, 2010·Molecular Carcinogenesis·Okkyung RhoJohn Digiovanni
Jan 1, 1989·Molecular Carcinogenesis·C M AldazC J Conti
Oct 6, 2000·Medical Hypotheses·F F Shadan, L P Villarreal
Feb 1, 1991·International Journal of Radiation Biology·U Weissenborn, C Streffer
Aug 1, 1996·The Journal of Dermatology·V N SehgalN Singh
Nov 1, 1994·The Journal of Investigative Dermatology·S H YuspaW C Weinberg

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