PMID: 7420414Sep 1, 1980Paper

Aneuploidy in culture

Journal of Mental Deficiency Research
A Smith, G Elliott

Abstract

On one hundred consecutive clinically referred patients, a total of 3,175 cells was fully analysed. The parameters of culture and analysis were the same for all patients, and a breakdown of cells showed 258 cells (8.1 per cent) with hypomodal counts and sixty-two cells (1.9 per cent) with hypermodal counts. The great majority of the hypomodal cells contained forty-five chromosomes and the distribution of chromosome loss from these cells was non-random, with fewer than expected of the large chromosomes (groups A, B and C) being lost, and more than expected of the small chromosomes (group E and G) being lost. The distribution of the chromosomes gained in the hypermodal cells was random (except for the C group where the numbers were small). In this data, there was no significant difference of aneuploidy in culture noted for sex, age, or patient referral group.

References

Oct 23, 1975·The New England Journal of Medicine·H J KimK Hirschhorn
Jan 1, 1971·Cytogenetics·F E Arrighi, T C Hsu
Oct 30, 1971·Lancet·M Seabright
Mar 25, 1972·Lancet·A G BaikieJ N Lickiss
Jan 1, 1972·Clinical Genetics·J Nielsen, U Friedrich
Sep 1, 1960·Experimental Cell Research·P S MOORHEADD A HUNGERFORD
Jan 16, 1960·Lancet·W M COURT BROWNR DOLL

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