Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation

Arteriosclerosis, Thrombosis, and Vascular Biology
Valentina PaloschiPer Eriksson

Abstract

Patients with bicuspid aortic valve (BAV) have an increased risk of developing ascending aortic aneurysms. Transforming growth factor-β (TGFβ) is a crucial factor of vascular remodeling, the impaired signaling of which can alter the structure and composition of the extracellular matrix. In this study, we analyzed the activity of TGFβ in aneurysmal and nonaneurysmal ascending aorta from BAV patients, using tricuspid aortic valve (TAV) patients as a reference group. The response to exogenous TGFβ was analyzed with regard to gene expression in primary aortic smooth muscle cells that were isolated from 7 BAV and 5 TAV patients and in valve fibroblasts from 7 BAV and 8 TAV patients. The set of genes that were significantly changed by TGFβ (217 genes) was compared with gene expression profiles of the ascending aorta from BAV and TAV patients (139 arrays). By principle component analysis, based on the 217 genes, gene expression differed significantly in the intima/media region between aneurysmal BAV and TAV aortas, driven by the response in TAV patients. During aneurysm development the levels of phosphorylated SMADs and the availability of free TGFβ were lower in BAV patients compared with TAV. Confocal microscopy analysis showed a hi...Continue Reading

References

Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·E PiekP Ten Dijke
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S DooleyA M Gressner
Feb 25, 2003·Nature Genetics·Enid R NeptuneHarry C Dietz
Jul 9, 2003·The Journal of Cell Biology·Andres F MuroFrancisco E Baralle
May 1, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrew Leask, David J Abraham
Sep 4, 2004·Circulation Research·Ehrin J Armstrong, Joyce Bischoff
Apr 28, 2005·Expert Review of Cardiovascular Therapy·Paul W M FedakRichard D Weisel
Sep 19, 2008·JAMA : the Journal of the American Medical Association·Nikolaos TzemosSamuel C Siu
Apr 9, 2009·Acta Biochimica Et Biophysica Sinica·Xiaohua YanYeguang Chen
Jun 29, 2010·Journal of the American College of Cardiology·Samuel C Siu, Candice K Silversides
Dec 15, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Valentina PaloschiPer Eriksson
Feb 24, 2011·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Evaldas GirdauskasThomas Kuntze
Dec 14, 2011·Frontiers in Physiology·Manoj ValluruNicola J Brown
Jun 16, 2012·Cardiology Research and Practice·Brigitte Laforest, Mona Nemer
Jul 28, 2012·Nature Genetics·Rosemary J Akhurst
Aug 21, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shohreh MalekiPer Eriksson
Nov 2, 2012·Current Opinion in Rheumatology·Biao Hu, Sem H Phan
Dec 19, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Carmela Rita BalistreriGiovanni Ruvolo
Mar 26, 2013·Journal of the American Heart Association·Dick WågsäterPer Eriksson
Jul 17, 2013·Experimental Biology and Medicine·Asish K GhoshDouglas E Vaughan
Jun 7, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick A Murphy, Richard O Hynes

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Citations

Dec 7, 2016·Pharmacogenomics·Nicole K WilsonMibava Leducq Consortium
Sep 23, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark W Majesky
May 26, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong Lu, Alan Daugherty
Feb 11, 2018·Scientific Reports·Hanna M BjörckUNKNOWN Mechanistic Interrogation of Bicuspid Aortic Valve associated Aortopathy (MIBAVA) Leducq Consortium
Aug 30, 2018·Current Vascular Pharmacology·Camilla Krizhanovskii, Anders Franco-Cereceda
Dec 10, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Anna MalashichevaVladimir Uspensky
Apr 9, 2020·Journal of cardiology·Lidia R BonsJolien W Roos-Hesselink

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