Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology

International Journal of Molecular Sciences
Albert BuschUdo Lorenz

Abstract

Limited comprehension of aneurysm pathology has led to inconclusive results from clinical trials. miRNAs are key regulators of post-translational gene modification and are useful tools in elucidating key features of aneurysm pathogenesis in distinct entities of abdominal and popliteal aneurysms. Here, surgically harvested specimens from 19 abdominal aortic aneurysm (AAA) and 8 popliteal artery aneurysm (PAA) patients were analyzed for miRNA expression and histologically classified regarding extracellular matrix (ECM) remodeling and inflammation. DIANA-based computational target prediction and pathway enrichment analysis verified our results, as well as previous ones. miRNA-362, -19b-1, -194, -769, -21 and -550 were significantly down-regulated in AAA samples depending on degree of inflammation. Similar or inverse regulation was found for miR-769, 19b-1 and miR-550, -21, whereas miR-194 and -362 were unaltered in PAA. In situ hybridization verified higher expression of miR-550 and -21 in PAA compared to AAA and computational analysis for target genes and pathway enrichment affirmed signal transduction, cell-cell-interaction and cell degradation pathways, in line with previous results. Despite the vague role of miRNAs for potenti...Continue Reading

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Citations

Jul 1, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
Jul 2, 2020·International Journal of Molecular Sciences·Emma PlanaManuel Miralles
Mar 14, 2018·Journal of Translational Medicine·Masood Abu-HalimaEckart Meese
Jan 4, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Areti MoushiEvy Bashiardes
Apr 30, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
Oct 27, 2020·Journal of Cardiovascular Pharmacology·Tingting HuangWei Wang
Aug 10, 2021·The Journal of Surgical Research·Robert B HawkinsAshish K Sharma

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Methods Mentioned

BETA
HISA
electrophoresis
PCR

Software Mentioned

CFX Manager
DIANA miRPath
Excel
microT
StatMiner
DIANA
CDS
AZ Analyser

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