Nov 1, 2018

Aneuvis: Web-based exploration of numerical chromosomal variation in single cells

BioRxiv : the Preprint Server for Biology
Daniel G PiqueJessica C Mar

Abstract

Aberrations in chromosomal copy number are one of the most common molecular features observed in cancer. Quantifying the degree of numerical chromosomal variation in single cells across a population of cells is of interest to researchers studying whole chromosomal instability (W-CIN). W-CIN, a state of high numerical chromosomal variation, contributes to treatment resistance in cancer. Here, we introduce aneuvis, a web application that allows users to determine whether numerical chromosomal variation exists between experimental treatment groups. The web interface allows users to upload molecular cytogenetic or processed whole-genome sequencing data in a cell-by-chromosome matrix format and automatically generates visualizations and summary statistics that reflect the degree of numeric chromosomal variability. Aneuvis is the first user-friendly web application to help researchers identify the genetic and environmental perturbations that promote numerical chromosomal variation.

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Mentioned in this Paper

PDXP
Cytogenetics
Environment
Research Personnel
Molecular_function
Chromosomes
Resistance Process
CIN-4 protein, C elegans
Malignant Neoplasms
Chromosomal Instability

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