A/New Jersey/76 influenza vaccine trial in seronegative schoolchildren: comparison of a subunit vaccine with a whole-virus vaccine

Medical Microbiology and Immunology
M JustA Moritz

Abstract

In the present vaccination trial, 202 seronegative schoolchildren comprising both sexes and aged 11 to 12 years were vaccinated i.m. in the upper arm with either the subunit vaccine at a dosage of 600 CCA or 200 CCA or with a whole-virus vaccine at a dosage of 200 CCA, using the double-blind procedure. Both vaccines were prepared from the strain A/New Jersey/76 (x 53a-recombinant). The vaccination was followed four weeks later by a booster injection. In tests of local and systemic reactogenicity, it was found that at both dosages the subunit vaccine caused a low frequency of minor adverse reactions. The whole-virus vaccine was marked by a significantly higher rate of adverse reactions, whether of the local or systemic variety. The whole-virus vaccine had, however, a higher immunogenicity than the subunit vaccine, and due to the relatively high rate of adverse reactions it causes, it is not recommended for the vaccination of seronegative children. Because of its low reactogenicity, the subunit vaccine can be given at higher dosage, and it is a matter for consideration whether a better antibody response might not result from two booster injections.

References

Jan 1, 1980·Comparative Immunology, Microbiology and Infectious Diseases·M MajerK Wiebe
Oct 17, 2006·American Family Physician·Steven E Roskos
Jan 1, 1981·Journal of Medical Virology·A L FrankT R Cate
Jan 1, 1982·Journal of Medical Virology·R Levy, Z Zakay-Rones
Jan 1, 1981·Scandinavian Journal of Infectious Diseases·S PyrhönenM Romo
Jan 1, 1986·Health Care for Women International·K Rose, D G Saunders
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Tom JeffersonEliana Ferroni
Feb 2, 2018·The Cochrane Database of Systematic Reviews·Tom JeffersonVittorio Demicheli

Citations

Dec 1, 1977·The Journal of Infectious Diseases·M GoldfieldW E Halperin
Dec 1, 1977·The Journal of Infectious Diseases·W P GlezenL H Taber
Jun 1, 1976·Postgraduate Medical Journal·H BachmayerG Schmidt
Mar 10, 1966·The New England Journal of Medicine·J A MorrisF A Loda

Related Concepts

Antibodies, Viral
Revaccination
Semisynthetic Vaccines
Vaccines
Influenza virus vaccine
Influenza
Vaccination
Antibody Formation
Antibody Studies (Procedure)
Trivalent influenza vaccine

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Biotechnology and Bioengineering
W J McAleerM R Hilleman
The Australian Journal of Experimental Biology and Medical Science
B J FeeryM G Evered
The New England Journal of Medicine
R J Rubin, M B Gregg
© 2020 Meta ULC. All rights reserved