Ang-(1-7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats

Nitric Oxide : Biology and Chemistry
Aline C O CostaIgor Dg Duarte

Abstract

Angiotensin-(1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously and induces nitric oxide release in several tissues. The L-arginine/NO/cyclic GMP pathway and ATP-sensitive K+ channels have been proposed as the mechanism of action for the peripheral antinociception of several groups of drug and endogenous substances, including opioids, non-steroidal analgesics, acetylcholine and others. The aim of the present study was to investigate the involvement of the L-arginine/NO/cGMP and KATP+ pathway on antinociception induced by angiotensin-(1-7). Paw pressure in rats was used to induce hyperalgesia via an intraplantar injection of prostaglandin E2 (2 μg/paw). Ang-(1-7) (2, 3 and 4 μg/paw) elicited a local peripheral antinociceptive effect that was antagonized by the nonselective NO synthase (NOS) inhibitor L-NOarg and the selective neuronal NOS (nNOS) inhibitor L-NPA. The selective inhibition of endothelial (eNOS) and inducible (iNOS) NOS by L-NIO and L-NIL, respectively, was ineffective at blocking the effects of a local Ang-(1-7) injection. In addition, the level of nitrite in the homogenized paw tissue, as determined by a colorimetric assay, indicated that exogenous Ang-(1-7) is able to induce...Continue Reading

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Citations

Sep 10, 2015·Drug Development Research·Claudia Ivonne Araiza-SaldañaVinicio Granados-Soto
Nov 14, 2018·European Journal of Pain : EJP·Yoshiki OgataKoichi Tan-No
May 14, 2021·Pain Reports·Mihály BaloghAndrew J Shepherd
May 4, 2021·British Journal of Pharmacology·Hannes SchmidtAchim Schmidtko
Aug 6, 2021·Frontiers in Pharmacology·Hichem BouchenakiClaire Demiot

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