ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia

American Journal of Physiology. Heart and Circulatory Physiology
Tsuneo KobayashiK Kamata

Abstract

We investigated the involvement of ANG II and phosphatidylinositol 3-kinase (PI3-K) in the enhanced aortic contractile responses induced by hyperinsulinemia in chronic insulin-treated Type 1 diabetic rats. Plasma ANG II levels were elevated in untreated compared with control diabetic rats and further increased in insulin-treated diabetic rats. Aortic contractile responses and systolic blood pressure were significantly enhanced in chronic insulin-treated diabetic rats compared with the other groups. These insulin-induced increases were largely prevented by cotreatment with losartan (an ANG II type 1 receptor antagonist) or enalapril (an angiotensin-converting enzyme inhibitor). LY-294002 (a PI3-K inhibitor) diminished the increases in contractile responses in ANG II-incubated aortas and aortas from chronic insulin-treated diabetic rats. The norepinephrine (NE)-stimulated levels of p110 delta-associated PI3-K activity and p110 delta protein expression were increased in aortas from insulin-treated diabetic compared with control and untreated diabetic rats, and chronic administration of losartan blunted these increases. Contractions were significantly larger in aortas from diabetic rats incubated with a low concentration (inducing ...Continue Reading

References

Jul 1, 1995·Physiological Reviews·G M Reaven
Apr 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·J E HallM Alonso Galicia
Jul 1, 1997·Lancet·E P Feener, G L King
Jan 22, 2000·The Journal of Clinical Investigation·Y KidoD Accili
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo Kobayashi, Katsuo Kamata
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Peter JacobsenHans-Henrik Parving
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoling SuRobert S Moreland
May 8, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Takayuki MatsumotoKatsuo Kamata
Jul 10, 2004·Circulation Research·Catherine Le BlancNathalie Macrez
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Sassan HafiziChristopher G Proud
Feb 12, 2005·Endocrinology·Chi-Chang JuanLow-Tone Ho
Mar 4, 2005·The Journal of Pharmacology and Experimental Therapeutics·Klaudia BudzynChristopher G Sobey

❮ Previous
Next ❯

Citations

Nov 3, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Qinghua PuAviv Hassid
Aug 25, 2011·Canadian Journal of Physiology and Pharmacology·Jae-Gak KimJu-Tae Sohn
Apr 9, 2008·Journal of Pharmacological Sciences·Yasuhiro TakenouchiKatsuo Kamata
May 14, 2016·Pflügers Archiv : European journal of physiology·Shun WatanabeTsuneo Kobayashi
Apr 3, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Kumiko TaguchiTsuneo Kobayashi
Jul 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tsuneo Kobayashi
Sep 20, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Shingo NemotoKatsuo Kamata
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kumiko TaguchiKatsuo Kamata
Aug 14, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Shingo NemotoTsuneo Kobayashi
Sep 1, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Tsuneo KobayashiKatsuo Kamata
Mar 7, 2021·International Journal of Molecular Sciences·Israel Pérez-TorresVerónica Guarner-Lans

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.