Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma

Scientific Reports
Eungyoung KimSang-Woo Kim

Abstract

Angelica gigas Nakai (AGN) is an oriental traditional medicine to treat anemia, dysmenorrhea, and migraine. However, its anti-lymphoma effect is yet to be tested. Here, we demonstrated that AGN and its major component decursin target Myc to suppress lymphomagenesis in vitro and in vivo. AGN inhibited cell viability in multiple B lymphoma cells, while sparing normal splenocytes and bone marrow cells. Increased cleaved PARP level and caspase 3/7 activity and the repression of survival-promoting AKT/mTOR and MAPK pathways downstream of BCR, were responsible for the pro-apoptotic effects of AGN. We found that Myc, a prominent downstream target of these signaling pathways, contributes to AGN-induced cell death. Moreover, co-treatment with AGN and a Myc inhibitor, JQ1 or 10058-F4 yielded synergistic cytotoxic activities against cancer cells with markedly reduced Myc expression. AGN downregulated Myc expression and suppressed tumorigenesis in Eμ-myc transgenic mice. The proapoptotic activities of AGN were recapitulated by decursin, indicating that the anti-tumor effect of AGN was mainly caused by decursin. These findings suggest that AGN and decursin possess potent anti-lymphoma activity, and combination therapies with AGN/decursin an...Continue Reading

References

Jan 1, 1995·Cancer·T C GreinerE S Jaffe
Aug 28, 1998·Science·G Evan, T Littlewood
Jun 23, 1999·Oncogene·C E NesbitE V Prochownik
Sep 5, 2002·American Journal of Hematology·Beamon Agarwal, Kikkeri N Naresh
Oct 3, 2003·Cancer Cell·G Steven Martin
Sep 3, 2004·Human Pathology·Jeong Hee Cho-VegaL Jeffrey Medeiros
Apr 2, 2005·Nature Reviews. Cancer·Ralf Küppers
Jan 18, 2006·Journal of Pediatric Surgery·Ilsa Gomez-CuretLeslie J Krueger
Jun 1, 2007·Journal of Pharmaceutical and Biomedical Analysis·Xiang-Lan PiaoHye Hyun Yoo
Oct 17, 2008·Genes & Development·Martin Eilers, Robert N Eisenman
Jun 25, 2009·Nature Reviews. Cancer·Thomas G Cotter
Apr 16, 2010·The New England Journal of Medicine·Georg Lenz, Louis M Staudt
Sep 6, 2011·Cell·Jake E DelmoreConstantine S Mitsiades
Jan 25, 2012·Immunology·Bebhinn Treanor
Apr 3, 2012·Cell·Chi V Dang
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Jinhui ZhangJunxuan Lü
Jun 21, 2012·Blood·Jennifer A WoyachJohn C Byrd
Sep 26, 2012·The Cancer Journal·Michael Y Choi, Thomas J Kipps
May 30, 2013·Haematologica·Alexandra ValeraUNKNOWN Grup per l’Estudi dels Limfomes de Catalunya i Balears (GELCAB)
May 31, 2014·Blood·Bruce D Cheson
Jul 11, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sally E TrabuccoHong Zhang
Sep 10, 2014·Biochimica Et Biophysica Acta·Tomasz SewastianikPrzemysław Juszczyński
Mar 26, 2015·Seminars in Hematology·Neha Mehta-Shah, Anas Younes
Aug 19, 2015·Seminars in Cell & Developmental Biology·Annie L HsiehChi V Dang
Sep 15, 2015·Nature·Chun Yew FongMark A Dawson
Oct 31, 2015·Cell Research·Carl G Engelke, Arul M Chinnaiyan
Nov 26, 2016·Scientific Reports·Vincent PillonelPatrick Matthias
Apr 15, 2017·Oncotarget·Reza Bayat MokhtariHerman Yeger
Nov 24, 2017·Pathology·Shaoying LiL Jeffrey Medeiros

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Citations

May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bitna KweonSeung-Heon Hong
Jun 25, 2019·Animal Cells and Systems·Sung Won LeeSung Ho Jeon
Jan 11, 2019·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seung Tack OhBoo Ahn Shin

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BETA
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flow cytometry
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Prism
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BD FACS Canto II
Motic Images Plus
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FlowJO

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