Angelica gigas Nakai Has Synergetic Effects on Doxorubicin-Induced Apoptosis

BioMed Research International
Yong-Joon JeonYe Sun Han

Abstract

Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement in the accuracy of an automated high-throughput screening system. In this study, we screened natural product libraries to detect compounds with anticancer effects using HeLa cells. Of the 420 plant extracts screened, the extract of Angelica gigas Nakai (AGN) was the most effective in reducing cell viability of HeLa cells. Markers of apoptosis, such as exposure of phosphatidylserine and cleavage of caspase-7 and PARP, were increased by treatment with the AGN extract. Treatment of the AGN extract increased expression of PKR as well as ATF4 and CHOP, the unfolded protein response genes. In addition, cotreatment of doxorubicin and the AGN extract significantly increased doxorubicin-induced apoptosis in HeLa cells. Decursin and decursinol angelate, which were known to have anticancer effects, were the main components of the AGN extract. These results suggest that the extract of AGN containing, decursin and decursinol an...Continue Reading

References

Nov 1, 1969·Biotechnology and Bioengineering·F ArcamoneC Spalla
Jun 8, 2004·Current Medicinal Chemistry·S D Sarker, L Nahar
Dec 29, 2004·Journal of Natural Products·Mark S Butler
Nov 22, 2005·Biochemical and Biophysical Research Communications·Soo Jung KimYoung Il Yeom
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Apr 22, 2008·Current Opinion in Chemical Biology·A Ganesan
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cheol-Hee YoonYong-Soo Bae
Jun 25, 2009·Current Medicinal Chemistry·Cristina CarvalhoPaula I Moreira
Jul 11, 2009·Science·Jesse W-H Li, John C Vederas
Dec 22, 2009·The Journal of Biological Chemistry·Jane L ArmstrongChristopher P F Redfern
Dec 21, 2010·Phytotherapy Research : PTR·Seung Hwa SonWon-Yoon Chung
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Sep 29, 2011·Journal of Experimental & Clinical Cancer Research : CR·Rebecca S Y Wong
Jan 19, 2012·Nature Reviews. Molecular Cell Biology·Claudio Hetz
Feb 22, 2012·Cancers·Ahmad R Safa, Karen E Pollok
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Jinhui ZhangJunxuan Lü
Nov 17, 2012·Cancer Cell·Guoliang QingM Celeste Simon
Jan 29, 2013·Cellular and Molecular Life Sciences : CMLS·Neysan DonnellyAfshin Samali
Jul 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jinsil JangSung-Hoon Kim
Jul 14, 2014·Acta Biochimica Et Biophysica Sinica·Yiming LiZhinan Chen
Jan 13, 2015·Journal of Cancer Research and Therapeutics·Sangeeta Rivankar
May 14, 2016·Nature Communications·Zhenhua XuJ Alan Diehl
Sep 16, 2016·EMBO Reports·Karolina Pakos-ZebruckaAdrienne M Gorman
Feb 12, 2017·Cardiovascular Drugs and Therapy·John V McGowanDerek M Yellon
Sep 21, 2017·Scientia pharmaceutica·Kandasamy SowndhararajanSongmun Kim
Dec 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chinreddy Subramanyam ReddySung Cheol Koo

❮ Previous
Next ❯

Citations

May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bitna KweonSeung-Heon Hong

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis