Angelica sinensis reduced Aβ-induced memory impairment in rats

Journal of Drug Targeting
Ming-Hua DuanZhi-Dong Qiu

Abstract

Studies have shown that Angelica sinensis (JiLin AoDong Medicine Industry Groups Co., Ltd., Jilin, China) root (AS) ameliorates various diseases, although its effects in Alzheimer's disease (AD) have not been elucidated. The present study examined the effects of AS in a rat model of AD. Positional Aβ injections were administered to rats. The behavioral effects of AS administration were examined using the Morris water maze, and the molecular effects on gene and protein expression, and apoptosis, were determined. AS reversed the social behavioral impairments observed in this rat model of Aβ-induced memory impairment. Western blot analysis also revealed lower hippocampal levels of Aβ and β-site amyloid precursor protein-cleaving enzyme. Terminal deoxynucleotidyl transferased UTP nick end labeling indicated that AS significantly inhibited apoptosis via effects on nuclear factor kappa B (NF-κB) signaling. Real-time PCR, enzyme-linked immunosorbent assay, and immunohistochemical staining indicated that AS effectively inhibited inflammation and upregulated expression of glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) in the hippocampus of this rat AD model. AS effectively rescued the sym...Continue Reading

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Citations

Dec 24, 2019·Frontiers in Pharmacology·Yuan MaShu-Long Yang
Nov 21, 2020·Journal of Alzheimer's Disease : JAD·Julio A Flores-CuadraMaria B Carreira
Apr 30, 2021·Tzu Chi Medical Journal·Wei WuLiShinn-Zong Lin
Aug 23, 2019·Aging and Disease·Seong Gak JeonMinho Moon

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