PMID: 7538830Feb 1, 1995Paper

Angina pectoris following cisplatin, etoposide, and bleomycin in a patient with advanced testicular cancer

The Annals of Pharmacotherapy
J RodriguezG Hernando

Abstract

To report a case of angina pectoris associated with chemotherapy for testicular cancer. An HIV-infected patient with massive retroperitoneal metastases of a mixed embryonal and undifferentiated teratocarcinoma was treated with cisplatin, etoposide, and bleomycin. While the patient was receiving the second course of chemotherapy, he developed several episodes of angina pectoris that responded to nitroglycerin. Coronary angiography excluded structural abnormalities in the coronary arteries. The patient was treated prophylactically with nifedipine during the 2 following courses of chemotherapy with no new ischemic events. Coronary vasospasm seemed to be responsible for the angina in this patient. Several pathogenetic mechanisms that could explain these vascular events are discussed, including the possible role of bulky metastatic disease. The combination of cisplatin, etoposide, and bleomycin for testicular cancer, perhaps associated with bulky metastatic disease, can induce vasospastic phenomena that might be life-threatening.

References

Dec 27, 1976·Virchows Archiv. A, Pathological Anatomy and Histology·A BurkhardtJ O Gebbers
May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C R NicholsL H Einhorn
Sep 1, 1981·Annals of Internal Medicine·N J VogelzangB J Kennedy

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Citations

Jul 31, 2003·Drugs·Uzair B Chaudhary, Jason R Haldas
Feb 18, 2009·Internal Medicine Journal·M A Marinella, R J Markert
Jan 31, 2020·Clinical Case Reports·Wataru SasakiHideo Fujita
Oct 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin D FloydMichael C Perry
Mar 30, 2016·Circulation·Joerg HerrmannKonstantinos Marmagkiolis

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