PMID: 3089465Jul 26, 1986Paper

Angina pectoris-like pain provoked by intravenous adenosine in healthy volunteers

British Medical Journal
C SylvénR Brandt


In a study to characterise the chest pain induced by adenosine this agent was given as a bolus into a peripheral vein to six healthy volunteers (five men) aged 30-44. On the first day the maximum tolerable dose was determined in each case. On the second day three doses of adenosine (one third, two thirds, and the full maximum tolerable dose) and three doses of saline were given single blind in randomised order. Thereafter aminophylline 5 mg/kg was given and the procedure repeated in a different randomised order. On the third day between two thirds and the full maximum tolerable dose was given followed by 10 mg dipyridamole intravenously and a second injection of the same dose of adenosine. Heart rate and atrioventricular blocks were recorded by electrocardiography. One minute after each dose of adenosine the chest pain was scored. The maximum tolerable dose of adenosine ranged from 10.6 to 37.1 mg. All subjects experienced uneasy central chest pain provoking anxiety. The pain radiated to the shoulders, ulnar aspect of the arms, epigastric area, back, and into the throat. The pain began about 20 seconds after the injection and lasted 10-15 seconds. Increasing the dose of adenosine increased the intensity of the pain. Administrat...Continue Reading


Nov 1, 1985·British Journal of Clinical Pharmacology·A H Watt, P A Routledge
Jul 1, 1982·Journal of Molecular and Cellular Cardiology·J SchraderE Gerlach
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Sep 16, 1983·European Journal of Pharmacology·R E Klabunde
Sep 1, 1981·British Journal of Pharmacology·D S McQueen, J A Ribeiro

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