Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course.

The American Journal of Medicine
G FrizzeraH Rappaport

Abstract

The clinical and pathologic findings in 24 patients with "angio-immunoblastic lymphadenopathy with dysproteinemia" (AILD) are presented. The patients' ages ranged from 44 to 80 years, with a median age of 68 years. The disease has an acute onset. In many respects, the clinical presentation is suggestive of malignant lymphoma. Generalized lymphadenopathy was always present. Hepatomegaly was found in 20 patients, splenomegaly in 17, constitutional symptoms in 20 and skin rashes in nine. Twenty patients had anemia, with positive Coombs' test in eight of 14 tested. Polyclonal hypergammaglobulinemia was found in 17 of 22 patients. Two patterns of evolution were recognizable: (1) long survival (24 to 67 months) without treatment or after the administration of intensive combination chemotherapy; and (2) rapid progression (one to 19 months) regardless of the treatment given. Sixteen patients died; postmortem examination in 10 cases showed the cause of death to be attributable to severe infection in eight patients, to renal disease in one and to cardiovascular disease in one. No evidence of malignant lymphoma was seen in any of these autopsies. Histologically, the disease is systemic, with specific lesions in the lymph nodes. The spleen...Continue Reading

Citations

Oct 1, 1978·Scandinavian Journal of Haematology·Y Matzner, A Polliack
Jan 1, 1979·Cancer·A LichtensteinD I Feinstein
Nov 1, 1977·Cancer·L R MatzB K Armstrong
Jan 1, 1978·CRC Critical Reviews in Clinical Laboratory Sciences·B Schnitzer
Nov 1, 1979·Journal of Clinical Pathology·S BanikP S Hasleton
Jul 1, 1979·Journal of Clinical Pathology·D Hayes, J H Robertson
Sep 1, 1979·Journal of Cancer Research and Clinical Oncology·G R KruegerA Schauer
Jan 1, 1986·Hematological Oncology·S Watanabe
Mar 1, 1986·Histopathology·D H Wright
Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·C KittasK Lennert
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H Knecht, K Lennert
Oct 15, 1984·Cancer·S VarsanoA Klajman
Aug 1, 1980·Annals of the Rheumatic Diseases·R S RothwellP Davis
May 1, 1982·Cancer·T V ColbyR A Warnke
Jul 1, 1981·Scandinavian Journal of Haematology·M T Sindram, G Fedder
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·K OhshimaM Takeshita
Jun 1, 1994·American Journal of Hematology·J W LynchR S Weiner
Nov 5, 1997·Clinical Rheumatology·P ManganelliS Pileri
Sep 23, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie E MartinLinda C Wang
Dec 8, 2009·British Journal of Haematology·Laurence de LevalPhilippe Gaulard
Jul 7, 1977·The New England Journal of Medicine·G FrizzeraC W Berard
Jan 1, 1978·Cancer·T J MyersW T Pastuszak
Jul 1, 1986·Veterinary Pathology·F M MooreR A DeLellis
Aug 1, 1978·Cancer·P A KosmidisM Stahl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.