Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

Theranostics
Bo Yu, Shusheng Wang

Abstract

Long noncoding RNAs (lncRNAs) represent a large subgroup of RNAs that are longer than 200 nucleotides and have no apparent protein coding potential. They have diverse functions in different biological processes by regulating chromatin remodeling or protein translation. This review summarizes the recent progress of lncRNAs in angiogenesis and vascular diseases. A general overview of lncRNA functional mechanisms will be introduced. A list of lncRNAs, which are termed "Angio-LncRs", including MALAT1, MANTIS, PUNISHER, MEG3, MIAT, SENCR and GATA6-AS, will be discussed regarding their expression, regulation, function and mechanism of action in angiogenesis. Implications of lncRNAs in vascular diseases, such as atherosclerosis, hypertension, vascular retinopathies and tumor angiogenesis will also be discussed.

Citations

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Methods Mentioned

BETA
ubiquitination
RNA-seq
pulldown
Assay
proximity ligation
transfection
xenograft

Software Mentioned

MANTIS
PUNISHER
CoroMarker

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