Angioedema Secondary to IV Tissue Plasminogen Activator Administration for Treatment of Acute Ischemic Stroke

Case Reports in Critical Care
Benjamin ChaucerManas Upadhyaya

Abstract

IV tissue plasminogen activator (tPA) is the treatment of choice for ischemic strokes that present within the treatment window. In the majority of patients, this offers an effective and often life-prolonging treatment in the acute setting. In a rare set of patients treated with IV tPA, side effects can be seen. One rare and potentially dangerous side effect is angioedema. We present the case of a patient treated for ischemic stroke who developed angioedema and discuss the etiology and risk factors for this rare, but dangerous side effect. Given the frequent and widespread use of tPA, awareness of the rare life-threatening side effects is paramount. This is of particular importance for practitioners in the acute care setting.

References

May 11, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Michael D HillUNKNOWN Canadian Alteplase for Stroke Effectiveness Study (CASES) Investigators
Sep 21, 2011·Air Medical Journal·Mark MaertinsMatthew Swider
Dec 3, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ana Sofia CorreiaMiguel Viana-Baptista
Nov 27, 2016·Postgraduate Medical Journal·Balaji KrishnaiahDavid Good

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Citations

Jun 12, 2019·Stroke; a Journal of Cerebral Circulation·Kilian FröhlichKlemens Winder

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