Angiogenesis: a new physiological role for N-arachidonoyl serine and GPR55?

British Journal of Pharmacology
W-S Vanessa Ho

Abstract

N-arachidonoyl serine (ARA-S) is one of a number of acyl amino acids recently identified in mammalian tissues. It has been referred to as an endocannabinoid-like lipid largely based on its structural similarities with the endocannabinoid, N-arachidonoyl ethanolamide (anandamide). However, little is known about its potential physiological functions and receptor targets. In this issue of the British Journal of Pharmacology, Zhang and colleagues show that ARA-S is a potent inducer of endothelial cell proliferation and migration, and angiogenesis in vitro. Furthermore, this pro-angiogenic action is mediated, at least partly, by activation of the poorly characterized, G-protein-coupled GPR55 receptor. ARA-S, via GPR55, increases phosphorylation of extracellular signal-regulated kinases and Akt, and vascular endothelial growth factor signalling. These exciting findings highlight the endothelium as an endogenous target for ARA-S and GPR55.

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Citations

May 13, 2014·International Journal of Molecular Sciences·János HaskóIstván A Krizbai
Mar 4, 2011·Trends in Pharmacological Sciences·Ruth A Ross
Jan 31, 2012·Biochimica Et Biophysica Acta·Roberto Piñeiro, Marco Falasca
Jun 27, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·John R Richards

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