Angiogenesis: a promising therapeutic target for ovarian cancer

Critical Reviews in Oncology/hematology
A BamiasEric Pujade-Lauraine

Abstract

Ovarian cancer is the leading cause of death from gynecological cancers. Primary treatment of advanced ovarian cancer (FIGO stages III and IV) until recently consisted of cytoreductive surgery and paclitaxel/carboplatin chemotherapy. The results of two randomized studies, showing prolongation of progression-free survival (PFS) by the addition of the anti-VEGF monoclonal antibody, bevacizumab, led to the approval of this agent for first-line treatment of this disease and indicate that angiogenesis is a promising therapeutic target. Angiogenesis is essential for oncogenesis but also the viability and expansion of ovarian cancer. Specifically, VEGF is involved in the formation of ascites and has a direct effect on ascites tumor cells as well as an immunosuppressive function. Apart from VEGF, PDGF, FGF and angiopoietins present a therapeutic interest. We are reviewing the results of published clinical studies using anti-angiogenic factors in advanced ovarian cancer.

References

Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold F Dvorak
May 3, 2003·The Journal of Clinical Investigation·Gabriele BergersDouglas Hanahan
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jul 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert F OzolsUNKNOWN Gynecologic Oncology Group
Dec 20, 2003·Cancer Immunology, Immunotherapy : CII·Michael PapamichailConstantin N Baxevanis
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Sep 8, 2004·Gynecologic Oncology·Huaizeng ChenWeiguo Lu
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael J GoodheartRichard E Buller
Nov 25, 2005·American Journal of Reproductive Immunology : AJRI·Brian BarnettTyler J Curiel
Dec 13, 2005·Experimental Cell Research·Masabumi Shibuya, Lena Claesson-Welsh
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C RudlowskiW Schroeder
Oct 4, 2006·Alimentary Pharmacology & Therapeutics·C EvansD Kumar
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Mar 27, 2007·Gynecologic Oncology·Ernest S Han, Bradley J Monk
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Jul 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A Burger
Jul 21, 2007·The Journal of Clinical Investigation·Marya F McCartyLee M Ellis
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A BurgerJoel I Sorosky
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen A CannistraWilliam McGuire
Dec 28, 2007·The New England Journal of Medicine·Kathy MillerNancy E Davidson
Jan 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agustin A GarciaAmit M Oza
Feb 13, 2008·Nature Clinical Practice. Oncology·Whitney A SpannuthRobert L Coleman
Apr 9, 2008·American Journal of Obstetrics and Gynecology·Chunhua LuAnil K Sood
May 9, 2008·The New England Journal of Medicine·Robert S Kerbel
Oct 22, 2008·Gynecologic Oncology·Robert E BristowDennis S Chi
Nov 13, 2008·International Journal of Cancer. Journal International Du Cancer·Ifat SherBrenda L Coomber
Dec 4, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hanna SallinenSeppo Yla-Herttuala
May 29, 2009·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Oct 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ursula A MatulonisRichard T Penson
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard T PensonSusana M Campos
Jan 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer L SpratlinS Gail Eckhardt
Mar 6, 2010·Cancer Chemotherapy and Pharmacology·Martin PölcherChristian Rudlowski
Mar 17, 2010·Critical Reviews in Oncology/hematology·Alberto QuagliaUNKNOWN Liguria Region Tumour Registry
Apr 17, 2010·Bulletin of Experimental Biology and Medicine·M M VysotskiiI B Manukhin
Jun 30, 2010·Gynecologic Oncology·Michael FriedlanderJoanne J Lager

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Citations

Jan 5, 2014·International Journal of Molecular Sciences·Goda G Muralidhar, Maria V Barbolina
Jul 3, 2013·Molecular Aspects of Medicine·Nuzhat AhmedJock K Findlay
Oct 31, 2013·Pharmaceutical Research·Lívia Palmerston MendesEliana Martins Lima
Jun 18, 2015·Oncology Reports·Chen YangXiaoqiu Liang
Nov 10, 2012·Critical Reviews in Oncology/hematology·Bradley J MonkIvor Benjamin
Jul 17, 2012·The Veterinary Journal·Christophe CasteleynChristophe Van Steenkiste
Feb 18, 2014·Journal of Ovarian Research·Merete Thune WiigerYvonne Andersson
Aug 1, 2015·Journal of Gastrointestinal Cancer·Shadi HamdehStephen Lanspa
May 23, 2015·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Amanda F BakerSetsuko K Chambers
Dec 17, 2016·Cellular Oncology (Dordrecht)·Khalid El BairiMariam Amrani
Apr 27, 2017·Critical Reviews in Clinical Laboratory Sciences·Khalid El BairiSaid Afqir
Nov 30, 2012·Expert Opinion on Biological Therapy·Takahito M MiyakeRobert L Coleman
Jul 19, 2014·Anti-cancer Drugs·Michal KielbikMagdalena Klink
Oct 2, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhengyi Ruan, Dong Zhao
Mar 15, 2014·International Journal of Oncology·Vincenza ConteducaUgo De Giorgi
Mar 27, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gregory D ConwayToni M Antalis
Jan 20, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Huilin YangJamie Spangler

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