Angiogenesis activity of Jatropha curcas L. latex in cream formulation on wound healing in mice

Veterinary World
Ummu BalqisMuhammad Nur Salim

Abstract

The aim of this research was to determine the angiogenesis activity of Jatropha curcas latex in cream formulation on CD34 immune expression during wound healing phase in mice skin. Amount of 36 2-month-old male mice were used between 30 and 40 g. To surgical procedures, wound skin incision was performed 2.0 cm in length until subcutaneous on the paravertebral of each animal. The treatment was carried under locally anesthetized with procaine cream. All mice were divided into four groups, namely the base cream as control group (A), sulfadiazine 0.1% cream (B), Jatropha curcas latex cream 10% (C), and J. curcas latex cream 15% (D). All groups were treated entire surface of wound. All experiments were performed twice a day for 10 days. Experiments were terminated on days 3, 7, and 10, respectively. The wound healing was assayed in stained histological section in immunohistochemical of the wounds. The CD34 expression was investigated under a microscope. The results showed that the cream from 10% and 15% latex J. curcas revealed moderate immune reaction to CD34 on days 3 and 7 in wound healing of mice skin. We concluded that the cream from 10% and 15% latex J. curcas has potential as angiogenesis activity in wound healing of mice skin.

References

Nov 7, 2008·Journal of Cell Science·Julie S Nielsen, Kelly M McNagny
Nov 26, 2009·The Journal of International Medical Research·Tomaz VelnarV Smrkolj
Feb 9, 2010·Journal of Dental Research·S Guo, L A Dipietro
Jul 7, 2011·The International Journal of Developmental Biology·Silvia NuceraMichele De Palma
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Raju N PatilDheeraj Ahirwar
Sep 22, 2011·Indian Journal of Pathology & Microbiology·Madhu Mati GoelApul Goel
Oct 4, 2012·Developmental Biology·Domenico Ribatti, Enrico Crivellato
Feb 6, 2014·Stem Cells·Laura E SidneyAndrew Hopkinson
Nov 10, 2015·Journal of Ethnopharmacology·Christian AgyareTheresa Appiah
Nov 2, 2016·Journal of Leukocyte Biology·Luisa A DiPietro

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Citations

Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lisa Efriani PuluhulawaNasrul Wathoni

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