Angiogenesis and biomarkers of cardiovascular risk in adults with metabolic syndrome.

Journal of Internal Medicine
Mario SiervoMarina Ciullo

Abstract

Metabolic syndrome (MetSyn) is associated with an increased risk of atherosclerosis and fatal cardiovascular events. Angiogenesis is thought to contribute to this risk as it might be involved in the progression of atherosclerotic plaques. We investigated the levels of circulating biomarkers of angiogenesis and cardiovascular risk in adults with MetSyn and assessed their association with established metabolic risk factors. The Genetic Park project is a highly inclusive cross-sectional survey (about 80% of residents) conducted in three isolated populations in Southern Italy. A total of 1000 men and women (age range: 18-98 years) were included in the analysis. Anthropometric and blood pressure measurements were recorded. Metabolic and cardiovascular biomarkers included glucose, triglycerides, total cholesterol, HDL, vascular endothelial growth factor, placental growth factor (PlGF), soluble fms-like tyrosine kinase-1, high-sensitivity C-reactive protein, high-sensitivity troponin T (hs-TnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Subjects with MetSyn had higher levels of PlGF and NT-proBNP after adjustment for age, smoking and body mass index. Circulating levels of PlGF, hs-TnT and NT-proBNP were directly related...Continue Reading

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Citations

Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
May 10, 2012·European Journal of Clinical Investigation·Mario SiervoLes J C Bluck
Nov 6, 2010·Journal of Internal Medicine·A D Blann
Apr 1, 2016·European Journal of Heart Failure·Wilson NadruzScott D Solomon
Jul 15, 2015·Genetic Testing and Molecular Biomarkers·Young Ree Kim, Seung-Ho Hong
Oct 3, 2012·Thrombosis Research·L BadimonM Borrell-Pagès
Oct 13, 2017·Current Medicinal Chemistry·Christos GeorgakopoulosDimitrios Tousoulis
Jan 11, 2021·Journal of Cardiac Failure·Anne S ErsbøllPeter Damm
Aug 5, 2021·Expert Opinion on Investigational Drugs·Bharat NarasimhanWilbert S Aronow

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