Angiogenesis and Blood-Brain Barrier Permeability in Vascular Remodeling after Stroke.

Current Neuropharmacology
Yi Yang, Michel T Torbey

Abstract

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke. By stimulating vessel growth, angiogenesis may stabilize brain perfusion, thereby promoting neuronal survival, brain plasticity, and neurologic recovery. However, therapeutic angiogenesis after stroke faces challenges: new angiogenesis-induced vessels have a higher than normal permeability, and treatment to promote angiogenesis may exacerbate outcomes in stroke patients. The development of therapies requires elucidation of the precise cellular and molecular basis of the disease. Microenvironment homeostasis of the central nervous system is essential for its normal function and is maintained by the blood-brain barrier (BBB). Tight junction proteins (TJP) form the tight junction (TJ) between vascular endothelial cells (ECs) and play a key role in regulating the BBB permeability. We demonstrated that after stroke, new angiogenesis-induced vessels in peri-infarct areas have abnormally high BBB permeability due to a lack of major TJPs in ECs. Therefore, promoting TJ formation and BBB integrity in the new vessels coupled with speedy angiogenesis will pro...Continue Reading

References

Mar 1, 1969·The Journal of Cell Biology·M W Brightman, T S Reese
Sep 1, 1994·Stroke; a Journal of Cerebral Circulation·J KrupinskiJ M Wang
Dec 1, 1993·The Journal of Cell Biology·M FuruseS Tsukita
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Oct 6, 2000·The Journal of Clinical Investigation·Z G ZhangM Chopp
Nov 30, 2000·Trends in Cardiovascular Medicine·M G MelaragnoB C Berk
Oct 23, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·U OzerdemW B Stallcup
Dec 26, 2001·Microvascular Research·Ugur OzerdemWilliam B Stallcup
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Karen S Mark, Thomas P Davis
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zheng Gang ZhangMichael Chopp
Apr 6, 2002·Circulation Research·Carmen UrbichStefanie Dimmeler
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·J D HuberT P Davis
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hedley C A Emsley, Pippa J Tyrrell
Feb 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takeshi HayashiPak H Chan
May 14, 2003·The Journal of Cell Biology·Takehiro NittaShoichiro Tsukita
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Jun 5, 2003·Annals of Neurology·Jieli ChenMichael Chopp
Jul 29, 2003·Cell and Tissue Research·Holger Gerhardt, Christer Betsholtz
May 29, 2004·Prostaglandins & Other Lipid Mediators·Sung-Suk ChaeTimothy Hla
Jun 23, 2004·Neurobiology of Disease·Praveen BallabhMaiken Nedergaard
Jul 20, 2004·Journal of Cellular Biochemistry·Bryan J McVerry, Joe G N Garcia
Jul 28, 2004·Investigative Ophthalmology & Visual Science·Suzanne Hughes, Tailoi Chan-Ling
Jul 31, 2004·Brain Research. Developmental Brain Research·Claudia M GarciaPatricia A D'Amore
Sep 24, 2004·Journal of Molecular and Cellular Cardiology·Matthew G MelaragnoBradford C Berk
Dec 21, 2004·Angiogenesis·Ugur Ozerdem, William B Stallcup
Jan 22, 2005·Fundamental & Clinical Pharmacology·Michael Schachter
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Majaz MoonisMarc Fisher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

American Journal of Physiology. Cell Physiology
Changjun YangEduardo Candelario-Jalil
Brain Research. Brain Research Reviews
Char-Huei Lai, Kuo-Hsing Kuo
© 2021 Meta ULC. All rights reserved