Angiogenesis and Ewing sarcoma--relationship to pulmonary metastasis and survival

Journal of Pediatric Surgery
Danko MikulićSven Seiwerth

Abstract

Intratumoral angiogenesis quantified by microvessel density (MVD) has been shown to be a strong prognostic indicator in a number of malignant tumors. Its association with prognosis in Ewing sarcoma has not been previously studied. The aim of our study was to investigate the relationship between angiogenesis and clinical outcome in Ewing sarcoma. Twenty-seven patients with Ewing sarcoma were included in a retrospective immunohistochemical study. Sections from diagnostic biopsies were immunostained using anti-von Willebrand factor antibody and microvessels were counted at 400x magnification on three microscopic fields per patient. Microvessel density was correlated with overall and disease-free survival as a continuous variable using univariate regression analysis and as a dichotomous variable by Kaplan-Meier and log-rank analysis. Correlation between clinicopathologic variables and the degree of angiogenesis was tested using chi(2) test. Increasing MVD was not confirmed to be a poor prognostic factor in univariate analysis. Also, statistically significant difference was not found in overall survival or disease-free survival between patients with high (>31.6 vessels per field) and low (<or=31.6 vessels per field) microvessel coun...Continue Reading

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Citations

May 17, 2012·Clinical Sarcoma Research·Annmeik M van MaldegemAndrew B Hassan
Jul 21, 2011·The American Journal of Pathology·Toshifumi FujiwaraYukihide Iwamoto
Jan 16, 2021·Cancers·Claudia Ollauri-Ibáñez, Itziar Astigarraga

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