Angiogenesis and Eye Disease

Annual Review of Vision Science
Yoshihiko UsuiMartin Friedlander

Abstract

The retina consists of organized layers of photoreceptors, interneurons, glia, epithelial cells, and endothelial cells. The economic model of supply and demand used to appropriately determine cost is highly applicable to the retina, in which the extreme metabolic demands of phototransduction are met by precisely localized and designed vascular networks. Proper development and maintenance of these networks is critical to normal visual function; dysregulation is characteristic of several devastating human diseases, including but not limited to age-related macular degeneration and diabetic retinopathy. In this article, we focus on the lessons learned from the study of retinal vascular development and how these lessons can be used to better maintain adult vascular networks and prevent retinal diseases. We then outline the vasculotrophic contributions from neurons, retinal pigment epithelium (RPE) cells, and glia (specifically microglia) before we shift our focus to pathology to provide molecular contexts for neovascular retinal diseases. Finally, we conclude with a discussion that applies what we have learned about how retinal cells interact with the vasculature to identify and validate therapeutic approaches for neurovascular dise...Continue Reading

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Citations

Jul 31, 2019·Investigative Ophthalmology & Visual Science·Beiying QiuXiaomeng Wang
Sep 26, 2020·Advanced Healthcare Materials·Héloïse RagellePeter D Westenskow
May 22, 2020·JCI Insight·Ayumi Usui-OuchiMartin Friedlander
Jun 4, 2020·Journal of Extracellular Vesicles·Roberta AngioniAntonella Viola
Sep 27, 2019·Experimental and Therapeutic Medicine·Xin GaoMing Zhong
Aug 14, 2019·The Journal of Clinical Investigation·Amir RattnerJeremy Nathans
Sep 18, 2018·Annual Review of Vision Science·Ye Sun, Lois E H Smith
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ayumi Usui-OuchiMartin Friedlander
Jul 11, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fan-Li LinGuei-Sheung Liu
May 22, 2021·The Journal of Clinical Endocrinology and Metabolism·Jie MinSlavica Tudzarova
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani

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Methods Mentioned

BETA
transfection

Clinical Trials Mentioned

NCT01362348
NCT00138632
NCT00992563
NCT00304954
NCT00766337
NCT00857259
NCT01271270
NCT01033721
NCT01414153
NCT00782093

Software Mentioned

DIRECT
VIEW

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