Angiogenesis and lymphangiogenesis in corneal transplantation-A review

Survey of Ophthalmology
Wei ZhongDimitri T Azar

Abstract

Corneal transplantation has been proven effective for returning the gift of sight to those affected by corneal disorders such as opacity, injury, and infections that are a leading cause of blindness. Immune privilege plays an important role in the success of corneal transplantation procedures; however, immune rejection reactions do occur, and they, in conjunction with a shortage of corneal donor tissue, continue to pose major challenges. Corneal immune privilege is important to the success of corneal transplantation and closely related to the avascular nature of the cornea. Corneal avascularity may be disrupted by the processes of angiogenesis and lymphangiogenesis, and for this reason, these phenomena have been a focus of research in recent years. Through this research, therapies addressing certain rejection reactions related to angiogenesis have been developed and implemented. Corneal donor tissue shortages also have been addressed by the development of new materials to replace the human donor cornea. These advancements, along with other improvements in the corneal transplantation procedure, have contributed to an improved success rate for corneal transplantation. We summarize recent developments and improvements in corneal t...Continue Reading

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Citations

Oct 24, 2018·The British Journal of Ophthalmology·Michael Adam DiamondNeeru Gupta
Apr 20, 2019·Chemical Biology & Drug Design·Jiahao ZhangYan Zhang
Feb 27, 2020·Journal of Clinical Medicine·Antonio Di ZazzoTakenori Inomata
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Jul 3, 2021·Biology·Mariela Subileau, Daniel Vittet

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