Angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma of minor salivary glands

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Frederico Omar Gleber-NettoMaria Cássia Ferreira Aguiar

Abstract

Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. This tumor is characterized by a great variability in clinical behavior, and little is known about the pathological mechanisms involved in its variance. Angiogenesis is an important step in tumor progression and is believed to be an essential event for metastatic dissemination. We aimed to investigate angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma measuring the density of neoformed and lymphatic vessels using CD105 and D2-40 antibodies, respectively, and by immunohistochemical evaluation of VEGF-A and VEGF-C proteins. It was also investigated the expression of D2-40 in neoplastic cells. We studied 26 cases of mucoepidermoid carcinoma, which showed great angiogenic activity measured by neoformed vessel density. However, a low density of lymphatics was observed. VEGF-A, VEGF-C, and D2-40 were commonly detected in mucoepidermoid carcinoma, but only VEGF-A expression correlated with neoformed vessel density. Recurrence and nodal metastasis were associated with low VEGF-A expression and low neoformed vessel density, indicating that impaired angiogenesis could lead to an aggressive phenotype. Angiogenesis seems important in the modulation ...Continue Reading

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Citations

May 10, 2015·Expert Opinion on Therapeutic Targets·Stamatios TheocharisJerzy Klijanienko
Jul 23, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Felipe P FonsecaPablo A Vargas
Nov 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L D LocatiL Licitra
Dec 12, 2020·International Journal of Molecular Sciences·Despoina PouloudiStamatios Theocharis
Feb 1, 2020·Experimental and Molecular Pathology·Keila Martha Amorim BarrosoLélia Batista de Souza

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