Angiogenesis and progression in human melanoma.

Dermatology Research and Practice
Roberto RiaA Vacca

Abstract

In tumor growth, angiogenesis, the process of new-formation of blood vessels from pre-existing ones, is uncontrolled and unlimited in time. The vascular phase is characterized by the new-formation of vascular channels that enhances tumor cell proliferation, local invasion and hematogenous metastasis. Human malignant melanoma is a highly metastatic tumor with poor prognosis, and high resistance to treatment. Parallel with progression, melanoma acquires a rich vascular network, whereas an increasing number of tumor cells express the laminin receptor, which enables their adhesion to the vascular wall, favouring tumor cell extravasation and metastases. Melanoma neovascularization has been correlated with poor prognosis, overall survival, ulceration and increased rate of relapse. Secretion of various angiogenic cytokines, i.e. VEGF-A, FGF-2, PGF-1 and -2, IL-8, and TGF-1 by melanoma cells promote the angiogenic switch and has been correlated to transition from the radial to the vertical growth phase, and to the metastatic phase. Moreover, melanoma cells overexpress alphavbeta3, alphavbeta5, alpha2beta1 and alpha5beta1 integrins and release, together with stromal cells, higher amount of metalloproteases that increasing their invasive...Continue Reading

References

Aug 15, 1994·Cancer Research·C DelbaldoA P Sappino
Dec 1, 1995·Annals of Surgery·J A Norton
Oct 1, 1996·Proceedings of the Society for Experimental Biology and Medicine·H P BirkenfeldP W Sylvester
Dec 1, 1996·The Surgical Clinics of North America·D D HeasleyM C Mihm
Jan 1, 1997·European Radiology·S GramppH Imhof
Jan 1, 1996·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·B Anand-ApteS S Apte
Jan 1, 1997·British Journal of Cancer·P SalvenH Joensuu
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Wojtowicz-PragaM J Hawkins
Jan 5, 1999·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M Bar-Eli
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·D RibattiF Dammacco
Aug 22, 2000·The Journal of Investigative Dermatology·U B HofmannD J Ruiter
Jan 2, 2001·British Dental Journal·I Needleman
Feb 24, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A RudekE Reed
Mar 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S Singhal, J Mehta
Mar 30, 2002·Science·Lisa M CoussensLynn M Matrisian
Nov 27, 2002·Investigational New Drugs·Ian QuirtUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Jan 17, 2003·Clinical Medicine : Journal of the Royal College of Physicians of London·A J Kvalsvig, D J Unsworth
Mar 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D RibattiF Dammacco
Apr 19, 2003·Experimental Dermatology·E Kerkelä, U Saarialho-Kere
Feb 27, 2004·Biochimica Et Biophysica Acta·Aernout LuttunPeter Carmeliet
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy C PetersonThomas F Gajewski
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Daniela JurekRolf Schulte-Hermann
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sharyn D BakerAlex Sparreboom
Jun 30, 2005·Cancer Metastasis Reviews·Silke KuphalAnja-Katrin Bosserhoff
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johanna NikkolaSeppo Pyrhönen
Oct 12, 2005·Journal of Dermatological Science·Teresa OdorisioGiovanna Zambruno
Feb 17, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anja K Bosserhoff
Jun 1, 2006·Cancer Chemotherapy and Pharmacology·Monica M MitaAmita Patnaik
Sep 13, 2006·Pigment Cell Research·Vladislava O Melnikova, Menashe Bar-Eli
Sep 23, 2006·Leukemia·D RibattiA Vacca
Sep 27, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele BascheS Gail Eckhardt

❮ Previous
Next ❯

Citations

Oct 12, 2012·Journal of Cell Communication and Signaling·Michael JewerLynne-Marie Postovit
Jun 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sangbin LeeYu-Kyoung Oh
Jan 21, 2012·Actas dermo-sifiliográficas·R M MartíA Yeramian
Oct 7, 2014·International Journal of Cancer. Journal International Du Cancer·Federica RuffiniPedro M Lacal
May 23, 2015·Frontiers in Oncology·Svenja Meierjohann
Mar 2, 2018·Medical Oncology·Dorota Ciołczyk-Wierzbicka, Piotr Laidler
Apr 29, 2015·International Journal of Molecular Sciences·Vladimir ZidlikJana Dvorackova
Jun 20, 2019·Cancers·Florian CastetJosep Maria Piulats

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.