Angiogenesis and tumor progression in neuroendocrine digestive tumors

The Journal of Surgical Research
Gilles PoncetColette Roche

Abstract

Clinical observations suggest that in neuroendocrine digestive tumors a high intratumoral microvascular density is associated with good prognosis. We used an experimental orthotopic xenograft model to analyze the relations between angiogenic activity and tumor progression in this tumor subset. We compared 2 endocrine cell lines: STC-1, a low vascular endothelial growth factor (VEGF)-producing cell line, and INS-r3, a high VEGF-producing cell line. Tumor cells were grafted in the adventitial layer of the caecal wall of nude mice, sacrificed after 8 wk. At 8 wk, "primary" tumors were present in all animals. STC-1 derived tumors were morphologically moderately differentiated, with high proliferative and apoptotic activities; in contrast, INS-r3 derived tumors were well differentiated, with low proliferative and apoptotic activities. VEGF was expressed in <50% grafted STC-1 cells but in >90% of grafted INS-r3 cells. Microvascular density was significantly higher in INS-r3 derived tumors than in STC-1 derived tumors. All STC-1 derived tumors (n = 8) have invaded the mucosa, in contrast to none of the INS-r3 derived tumors (n = 8); liver metastases were detected in 7/8 animals bearing STC-1 derived tumors and in 0/8 animals with INS-...Continue Reading

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Citations

Jul 11, 2013·Journal of the National Cancer Institute·Jianliang ZhangSteven N Hochwald
Jan 20, 2011·World Journal of Gastroenterology : WJG·Patricia KuiperHein W Verspaget
Sep 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Omar Abdel-Rahman
Jul 6, 2015·Cancer Treatment Reviews·Chiara Alessandra CellaNicola Fazio
Jan 13, 2011·The American Journal of Pathology·Christophe CoudercColette Roche
Jan 19, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Omar Abdel-Rahman, Mona Fouad
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Apr 28, 2012·Neuroendocrinology·Jean-Yves Scoazec
Apr 28, 2012·Neuroendocrinology·Simona Grozinsky-GlasbergHadara Rubinfeld
May 18, 2018·Endocrine-related Cancer·Federica GrilloUNKNOWN NIKE Group
Dec 12, 2018·Pancreas·Bhavina D O Batukbhai, Ana De Jesus-Acosta
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Jul 1, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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