PMID: 7542814Jul 27, 1995Paper

Angiogenesis and vascularization of murine pancreatic islet isografts

Transplantation
P VajkoczyK Messmer

Abstract

Although the microvascular endothelium has been identified as the primary target site for the initiation of pancreatic islet graft rejection, little is known of the microvascular and cellular mechanisms involved, partly due to the lack of adequate models. Herein, we present a model for the in vivo assessment of the microcirculation of pancreatic islet grafts in mice. Isolated islets of Langerhans from immunocompetent hairless mice and immunoincompetent athymic nude mice were transplanted syngeneically into a specially designed dorsal skinfold chamber mounted on nondiabetic recipients. The islets' microcirculation was visualized by means of intravital fluorescence microscopy, and microcirculatory parameters were quantitatively analysed over a period of 14 days in the awake animal. Between day 2 and 4 after transplantation 84% (31/37; hairless mice) and 69% (36/52; nude mice) of the islet grafts revealed capillary sprouts and formation of new microvessels. On day 6, these sprouts were found interconnected, and red blood cell movement within the newly formed microvascular network was observed. The process of angiogenesis and revascularization was completed within 10 days after transplantation yielding a glomerulus-like network of ...Continue Reading

Citations

Mar 27, 2001·Transplantation Proceedings·C RastelliniS Morini
Nov 15, 2002·Transplantation Proceedings·J-H JuangB R-S Hsu
Jun 1, 1997·Transplantation Proceedings·P FiedorM A Hardy
Dec 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Subhadra C GunawardanaDavid W Piston
Dec 11, 2008·Molecular Pharmaceutics·Ravikiran Panakanti, Ram I Mahato
Jan 17, 2013·World Journal of Gastroenterology : WJG·Denis Dufrane, Pierre Gianello
May 27, 2009·Current Opinion in Organ Transplantation·Alain J PonceletPierre Gianello
Oct 8, 2014·Plastic and Reconstructive Surgery. Global Open·Ataru SunagaEiji Kobayashi
Jul 19, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Göran MattssonLeif Jansson
Mar 2, 2005·Journal of the American College of Surgeons·Neal R BarshesJohn A Goss
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·P VajkoczyM D Menger
May 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P VajkoczyM D Menger
Mar 26, 2011·Thrombosis and Haemostasis·R T A MegensO Soehnlein
Dec 5, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A-R KuehlB Vollmar
Dec 18, 2009·Clinical Transplantation·Dan RidgwaySteve White
May 6, 2015·Pediatric Transplantation·Dixon B Kaufman, Jonathan S Rink
Jun 26, 2015·PloS One·Yuichi MasudaHirohito Ichii
Jan 22, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Vaihere DelauneChristian Toso
Mar 25, 2016·World Journal of Transplantation·Uriel BarkaiPaul de Vos

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