PMID: 7544962Sep 1, 1995Paper

Angiogenesis as a prognostic marker in early head and neck cancer

The Annals of Otology, Rhinology, and Laryngology
T G DrayR A Sofferman

Abstract

Experimental evidence suggests that tumor growth beyond the earliest stages is dependent on angiogenesis, or neovascularization, and that angiogenesis may also promote metastasis. Recent clinical studies demonstrate that angiogenesis is a prognostic marker in breast, lung, and prostate cancer. To investigate whether tumor angiogenesis also correlates with metastasis and survival in early head and neck carcinoma, we quantified the microvascularity of 106 primary carcinomas prior to treatment and correlated the counts with eventual outcome after 3 to 15 years of follow-up. Microvessels were stained immunocytochemically for von Willebrand factor and then counted by light microscopy. Microvessels were counted per 200x and 400x fields, and their density was graded from 1 to 4, in the area of most intense neovascularization. We found that neither microvessel counts nor density grades correlated with metastatic disease, local recurrence, or survival in early head and neck carcinoma. These results are in contradistinction to those recently reported for other tumor sites.

References

Dec 16, 1992·Journal of the National Cancer Institute·N WeidnerG Gasparini
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Oct 1, 1986·European Journal of Cancer & Clinical Oncology·A SrivastavaE J Shedden
Apr 1, 1987·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M M GoldsmithH C Pillsbury
Dec 1, 1986·Archives of Surgery·C MooreR A Greenberg
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 1, 1993·The Annals of Otology, Rhinology, and Laryngology·G J PetruzzelliE N Myers

❮ Previous
Next ❯

Citations

Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Jun 6, 2000·Critical Reviews in Oncology/hematology·J P MetgesP Wibault
Jun 24, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B V OffersenJ Overgaard
Aug 17, 2002·International Journal of Radiation Oncology, Biology, Physics·Anna S E LjungkvistJuliana Denekamp
Jan 5, 2000·BJU International·S J Foley, D M Bailey
Jul 27, 2005·Journal of Cancer Research and Clinical Oncology·Panayiotis A KyzasNiki J Agnantis
Oct 24, 2007·Acta otorrinolaringológica española·Mario M FernándezPablo L Parente
Feb 8, 2005·Oral Oncology·Tiziana MartoneGiorgio Cortesina
Nov 28, 1997·American Journal of Surgery·J D MurrayC Cohen
Oct 10, 2009·Acta otorrinolaringológica española·Juan Pablo RodrigoCarlos Suárez Nieto
Nov 28, 1997·American Journal of Surgery·B L RichardsD L Kreutzer
Nov 28, 1997·American Journal of Surgery·R J EismaD L Kreutzer
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M W Lingen
Aug 1, 1998·Otolaryngologic Clinics of North America·G J PetruzzelliS Yong
Mar 28, 2001·The Annals of Otology, Rhinology, and Laryngology·B D SmithC T Sasaki
Aug 16, 2000·Clinical Otolaryngology and Allied Sciences·J J HomerN D Stafford
Apr 14, 2000·Clinical Otolaryngology and Allied Sciences·J GreenmanN D Stafford
Jun 26, 2001·Histopathology·K N NareshA M Borges
Nov 6, 2009·Thyroid : Official Journal of the American Thyroid Association·Vergilius José Furtado de Araujo-FilhoAlberto R Ferraz
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Panayiotis A KyzasNiki J Agnantis
Jan 25, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marcos Vinícius M de OliveiraAlfredo M B De Paula
May 8, 2001·International Journal of Cancer. Journal International Du Cancer·L PignataroG Pruneri
Apr 3, 1998·Annals of Surgical Oncology·N C SaenzM F Brennan
Feb 24, 2001·Pathology, Research and Practice·N Sion-VardyD Benharroch
Oct 31, 2000·Current Problems in Surgery·A Y Chen, J N Myers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.