Angiogenesis for tumor vascular normalization of Endostar on hepatoma 22 tumor-bearing mice is involved in the immune response

Oncology Letters
Qingyu XuGuowen Yin

Abstract

Tumor vascular normalization involved in immune response is beneficial to the chemotherapy of tumors. Recombinant human endostatin (Endostar), an angiogenesis inhibitor, has been demonstrated to be effective in hepatocellular cancer (HCC). However, its vascular normalization in HCC and the role of the immune response in angiogenesis were unclear. In the present study, effects of Endostar on tumor vascular normalization were evaluated in hepatoma 22 (H22) tumor-bearing mice. Endostar was able to inhibit the proliferation and infiltration of tumor cells and improve α-fetoprotein, tumor necrosis factor-α and cyclic adenosine 5'-phosphate levels in the serum of H22-bearing mice, as well as the protein expression levels of the immune factors interferon-γ and cluster of differentiation (CD)86 in liver tissue. Endostar also exhibited more marked downregulation of the levels of vascular endothelial growth factor, CD31, matrix metalloproteinase (MMP)-2, MMP-9 and interleukin-17 during day 3-9 treatment, resulting in short-term normalization of tumor blood vessels. The period of vascular normalization was 3-9 days. The results of the present study demonstrated that Endostar was able to induce the period of vascular normalization, contrib...Continue Reading

References

Dec 22, 1998·The American Journal of Gastroenterology·N BayatiS C Gordon
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jan 8, 2003·Seminars in Oncology·Judah Folkman
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Oct 28, 2004·Gastroenterology·Jordi BruixJosep M Llovet
Jan 11, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joseph F MurphyAideen C Long
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tsutomu FujiiAkimasa Nakao
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Eldad S Bialecki, Adrian M Di Bisceglie
Apr 29, 2008·Cancer Immunology, Immunotherapy : CII·Arjan W Griffioen
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ahsun RiazRiad Salem
Feb 5, 2010·Journal of Cancer Research and Clinical Oncology·Guichun Huang, Longbang Chen
Jan 8, 2011·International Journal of Cancer. Journal International Du Cancer·Wenxiu ZhaoXiaomin Wang
Mar 26, 2011·Expert Opinion on Investigational Drugs·Chloé RancouleJean-Sébastien Saulnier-Blache
Nov 20, 2012·The Journal of Surgical Research·Nicholas J SkillMary A Maluccio
Jun 27, 2014·BioMed Research International·Luís Silva MonteiroHassan Bousbaa
Sep 10, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Manoj K SabnaniNinh M La-Beck
Jan 23, 2015·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Guoquan FengJingyi Liu
Mar 18, 2015·Journal of the National Cancer Institute·Allison S BetofMark W Dewhirst
Mar 20, 2015·Molecular Cancer Therapeutics·Shan WangYongzhang Luo
May 20, 2015·Gastroenterology Research and Practice·Qing YeXiaojin Yin
May 20, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shao-Rong GaoAi-Rong Wang
May 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian-Yang AoHui-Chuan Sun
May 31, 2015·Biochemical and Biophysical Research Communications·Hao HuangLu Qian
Jun 2, 2015·Oncogenesis·R N Gacche
Jul 23, 2015·Journal of Biomedical Science·M Afzal KhanD C Broering

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Citations

Oct 10, 2018·International Journal of Molecular Sciences·Yasuo TanakaKazuhiko Koike

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Methods Mentioned

BETA
ELISA
light microscopy

Software Mentioned

Endostar
SPSS
Primer Premier
Pro Plus
Image

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