Angiogenesis, immune system and growth factors: new targets in colorectal cancer therapy

Expert Review of Anticancer Therapy
Massimo C FantiniMarkus F Neurath

Abstract

Colorectal cancer is the second most common malignant human neoplasia. Over recent years, many efforts have been performed in order to develop and improve therapeutic protocols, and many advances have been accomplished in both the field of adjuvant and palliative therapy. Most of the chemotherapic agents currently used in the clinical setting are the products of decades of research aimed at inhibiting the uncontrolled growth of dysplastic cells. However, new frontiers in this field have recently been opened, with the identification of key molecules involved in physiologic mechanisms that are of fundamental importance for cancer development and progression. Tumor-induced angiogenesis, the cancer-immune system crosstalk and the effect of growth factors on dysplastic cells represent new fields of investigation for anticancer therapy.

References

Aug 12, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lukas J A C HawinkelsC F M Sier

Citations

Nov 22, 1991·Science·S A Aaronson
Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·K KoretzP Möller
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M Farber
Dec 1, 1990·The British Journal of Surgery·R J SteeleO Eremin
Oct 1, 1987·The Journal of Experimental Medicine·A D Luster, J V Ravetch
Jan 1, 1989·Acta Neuropathologica·M L RossiH B Coakham
Apr 5, 1989·Journal of the National Cancer Institute·H F Dvorak, I Gresser
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·T HaliotisJ C Roder
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Jul 15, 1982·International Journal of Cancer. Journal International Du Cancer·E GorelikR B Herberman
Oct 9, 1980·The New England Journal of Medicine·M B Sporn, G J Todaro
Jul 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R E Friesel, T Maciag
Jan 1, 1995·Annual Review of Cell and Developmental Biology·W Risau, I Flamme
Feb 1, 1997·Endocrine Reviews·N Ferrara, T Davis-Smyth
Jan 23, 1999·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·A Ekbom
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·L M WiseS A Stacker
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·A Wells

Related Concepts

Immune System
Epidermal Growth Factor
Angiogenic Process
Immunologic Adjuvants
Adjuvant
Neoplasms
Tumor Angiogenesis
Cross Reactions
Colorectal Neoplasms
Neoplastic Disease

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