Angiogenesis in ectopic ovarian xenotransplantation: multiparameter characterization of the neovasculature by dynamic contrast-enhanced MRI

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Tomer IsraelyMichal Neeman

Abstract

It has been suggested that ovarian cryopreservation and xenotransplantation can be used to preserve oocytes from damage during anticancer treatments. The main obstacle to subsequent ovarian grafting is loss of oocytes due to impaired perfusion. The aim of this study was to characterize angiogenic events following ovary xenotransplantation. Rat ovaries were transplanted into or onto the muscle of immunocompromised CD1-nude mice. Ovariectomy (OVX) of host mice prior to transplantation supported the resumption of follicular development, as manifested by the prevalence of antral follicles and corpora lutea. Two days after transplantation, the grafts were devoid of blood supply. Functional vessels within the graft were detected by MRI and histology from day 7 and on. By 2-3 weeks, both blood volume fraction and permeability in the graft, as measured with the use of albumin-based MR contrast material, were significantly elevated relative to the adjacent muscle. Extravasation of contrast material from the graft neovasculature was followed by interstitial convection in the muscle surrounding the graft, and draining toward the proximal popliteal lymph node. Development of the vasculature was monitored noninvasively, providing a time sca...Continue Reading

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Citations

Jun 1, 2010·Angiogenesis·Katrien VandoorneMichal Neeman
Oct 31, 2008·Journal of Assisted Reproduction and Genetics·Hiroshi SuzukiHideki Saitoh
Sep 26, 2013·Journal of Assisted Reproduction and Genetics·Lin WangJian Xu
Aug 6, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Vicki PlaksMichal Neeman
May 29, 2009·Human Reproduction Update·I DemeestereY Englert
Oct 29, 2010·Biology of Reproduction·Vicki PlaksAlon Harmelin
Jun 25, 2005·Current Opinion in Obstetrics & Gynecology·Jacques DonnezAnne Van Langendonckt
Nov 5, 2010·Clinical Obstetrics and Gynecology·Mohamed A Bedaiwy, Tommaso Falcone
Sep 25, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Jose R Rodriguez-SosaAnn Hahnel
Mar 4, 2014·Molecular Human Reproduction·A Van LangendoncktM M Dolmans
Feb 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Monireh MahmoodiAbdulhussein Shahverdi
Feb 2, 2016·Biopreservation and Biobanking·Maryam Akhavan TaheriBita Ebrahimi
Jun 5, 2012·Fertility and Sterility·Michael GrynbergNelly Frydman
Aug 3, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Byung Chul JeeShin Yong Moon
Jan 17, 2009·Reproductive Biomedicine Online·Hussein EimaniAbdolhossein Shahverdi
Jan 16, 2008·Journal of Cellular and Molecular Medicine·R A TownerF Lupu
Jun 24, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Katrien VandoorneMichal Neeman
Nov 20, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dandan WuYing Zhou
Mar 20, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jaesook Roh, Woojin Pi
Jun 23, 2009·Fertility and Sterility·Anne-Sophie Van EyckMarie-Madeleine Dolmans
Oct 3, 2015·Obstetrics & Gynecology Science·Won-Jun ChoiJong-Hak Lee
Apr 7, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vicki PlaksMichal Neeman
Mar 21, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Marie-Madeleine DolmansDiego Manavella
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Oct 8, 2020·Journal of Assisted Reproduction and Genetics·Camille HossayMarie-Madeleine Dolmans
Aug 14, 2021·Reproductive Biomedicine Online·Luciana CacciottolaMarie-Madeleine Dolmans

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