PMID: 7545803Oct 1, 1995Paper

Angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma

Obstetrics and Gynecology
O AbulafiaF Ghezzi

Abstract

To evaluate angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma, and to investigate the relationship between angiogenesis and tumor grade and depth of invasion. Three groups of patients were analyzed: control patients who underwent hysterectomy for benign conditions (n = 19), patients with endometrial hyperplasia (n = 24), and patients with stage I endometrial carcinoma (n = 34). All hysterectomy specimens were stained immunohistochemically for factor VIII-related antigen as a sensitive and specific marker for vascular endothelium. Areas close to the deepest myometrial invasion or those with the highest grade of endometrial hyperplasia and the highest angiogenic intensity were selected. Three fields (x 400) were selected for each slide, and the mean microvessel count was calculated. Statistical analysis included Mann-Whitney U test or Kruskal-Wallis analysis of variance and Dunn post hoc procedure. P < .05 was considered significant. A significant difference was found between the microvessel count of controls versus the group with complex endometrial hyperplasia (median 21, range 16-80, versus median 38, range 20-130; P < .05). Microvessel counts of complex endometrial hyperplasia were significantly higher...Continue Reading

Citations

Aug 15, 1997·Cancer·T KakuH Nakano
Mar 30, 2004·Gynecologic Oncology·Sabas Carlos VieiraNatália Guimarães De Moraes
Jul 26, 2000·Obstetrics and Gynecology·C A BrewerM E McAsey
Mar 13, 1999·Obstetrics and Gynecology·A ObermairC Kainz
Jul 2, 1999·Obstetrics and Gynecology·O Abulafia, D M Sherer
Mar 22, 2003·Gynecologic Oncology·Antonia Carla TestaGiovanni Scambia
May 30, 2002·Maturitas·Sanja KupesicElmira Hajder
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N Weidner
Feb 14, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Helga B Salvesen, Lars A Akslen
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ozlem ErdemAhmet Erdem
Jun 24, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Reda S SaadJan F Silverman
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C TaskiranH Guner
Nov 28, 2012·European Journal of Clinical Investigation·Giannoula SouflaDemetrios A Spandidos
Jun 1, 1997·Primary Care·B S Apgar, G R Newkirk
Jan 6, 2001·Baillière's Best Practice & Research. Clinical Obstetrics & Gynaecology·M R BrownE C Kohn
Mar 26, 2010·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R GalvánJ L Alcázar
Feb 22, 2005·International Journal of Cancer. Journal International Du Cancer·Veera NäyhäFrej Stenbäck
Nov 7, 2008·Journal of Experimental & Clinical Cancer Research : CR·Elzbieta Miszczak-ZaborskaJacek Bartkowiak
Jun 11, 2005·Cell and Tissue Research·Andrew J RyanMartin K Oehler
Sep 25, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ingeborg B EngelsenHelga B Salvesen
Oct 31, 2008·The Journal of Obstetrics and Gynaecology Research·Peter Uharcek
Sep 29, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Luis T MercéJosé M Bajo
Oct 16, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Bahar Yetkin-ArikCornelis J F van Noorden
Feb 18, 1999·Gynecologic Oncology·O AbulafiaD M Sherer
Mar 30, 1999·Gynecologic Oncology·D V HorbeltN J Walker-Bupp
May 29, 2004·American Journal of Obstetrics and Gynecology·Maria Angélica M GaiottoIsmael D C Guerreiro da Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.