PMID: 18723951Aug 30, 2008Paper

Angiogenesis in liver cirrhosis and hepatocellular carcinoma

Indian Journal of Pathology & Microbiology
Anjali D AmarapurkarV Kim

Abstract

Angiogenesis has been well documented in hepatocellular carcinoma (HCC). As liver cirrhosis is considered preneoplastic condition, the aim of this study was to evaluate the process of angiogenesis using CD 34 as an endothelial cell marker in normal liver, cirrhosis and HCC. A total of 111 cases were included in this study, which consisted of 30 cases each of normal liver and cirrhosis that were all autopsy cases. Twenty-one cases of HCC included 10 autopsy specimens, nine surgically resected specimens and two liver biopsies. Remaining were 30 cases of metastasis to the liver, which included 20 autopsy specimens, one surgically resected specimen and nine liver biopsies. The patients were between the age range from 17 to 80 years with 70 males and 11 females. Paraffin-embedded liver sections of all these cases were stained routinely by hematoxylin-eosin stain, while immunohistochemistry for CD 34 was performed for expression of endothelial cells. The positivity of CD 34 staining was evaluated by counting in 10 high-power field, grading was done from 0 to 4 and compared between normal liver, cirrhosis and HCC and metastasis. CD 34 was positive in 16/30 (53.3%) cases of cirrhosis, 18/21 (85%) cases of HCC and 26 (86.6%) of metastas...Continue Reading

Citations

Mar 11, 2015·Journal of Clinical and Experimental Hepatology·Ashish KumarUNKNOWN (The INASL Task-Force on Hepatocellular Carcinoma)
Nov 16, 2010·Annals of Diagnostic Pathology·Alma Ortiz-PlataMartha Lilia Tena-Suck
Feb 24, 2015·Biochemical and Biophysical Research Communications·Guanxiong YeDebiao Pan
Jul 14, 2009·Pathology, Research and Practice·Andrzej GabrielJoanna Musialik
Dec 14, 2017·World Journal of Surgical Oncology·Yingying YuDi Wu
Nov 24, 2019·Clinical Journal of Gastroenterology·Mohamed AzzazaAli Ben Ali
Mar 14, 2019·Annals of Hepato-biliary-pancreatic Surgery·Devayani NiyogiShraddha Patkar
Nov 5, 2014·Liver International : Official Journal of the International Association for the Study of the Liver·Jan PfeiffenbergerKarl Heinz Weiss
Aug 24, 2010·Molecular Cancer·Femke HeindryckxHans Van Vlierberghe

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