Angiogenesis in malignant fibrous histiocytoma

Oncology
M OhsawaK Aozasa

Abstract

The significance of neovascularization for tumor growth and metastasis has recently been postulated for human cancers; increased microvessel density correlates with increased frequency of metastasis. In the present study, microvessel density was examined in 42 cases of malignant fibrous histiocytoma (MFH). Microvessels were defined as lumens surrounded by anti-factor-VIII-related antigen (FVIII-RA)-antibody-stained endothelium, and counted in a x 400 field. The number of microvessels varied from 4 to 79 (median 14.5). When cases were divided into groups with less than or greater than 20 microvessels, there were no prominent differences in age distribution, sex ratio, size of tumor, depth of tumor, and histologic subtypes between the two groups. The number of microvessels in 19 cases with and 22 cases without metastasis was 19.4 +/- 14.9 and 19.6 +/- 17.4, respectively. Angiogenesis is apparently not a key factor in the formation of metastasis by MFH.

Citations

Jul 1, 1996·The Journal of Pathology·S B FoxA L Harris
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Piotr RutkowskiJan Steffen
Oct 2, 2002·Current Oncology Reports·G Thomas Budd
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M Ellis, I J Fidler
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M EllisD B Evans
Aug 15, 2003·Surgical Oncology Clinics of North America·Rosa F Hwang, Kelly K Hunt
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kolja EppertIrene L Andrulis
Jul 18, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T SatoK Sugihara
May 13, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Kevin L TaylorDaniel J Lindner
Jun 29, 2001·Current Opinion in Oncology·J V Heymach
Jul 24, 2001·Journal of Pediatric Hematology/oncology·E MantadakisC Timmons
Feb 10, 2000·The American Journal of Pathology·R FolbergA J Maniotis
Nov 20, 2015·Frontiers in Oncology·Monika Ehnman, Olle Larsson
Feb 1, 2007·Cancer·Steven DuBois, George Demetri
Dec 25, 2008·International Journal of Cancer. Journal International Du Cancer·Yoshinao OdaMasazumi Tsuneyoshi
Mar 7, 2006·Journal of Pediatric Surgery·Danko MikulićSven Seiwerth
Jul 5, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C C WestM W R Reed
Sep 23, 2014·Bioscience Reports·Laura RocchiDomenica Mangieri
Jan 1, 2005·Pediatric Hematology and Oncology·Danko MikulićSven Seiwerth
Mar 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Veera Näyhä, Frej Stenbäck
Apr 3, 1998·Annals of Surgical Oncology·N C SaenzM F Brennan
Feb 5, 2021·Journal of Clinical Medicine·Joanna RadzikowskaWojciech Kukwa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.