Abstract
Two processes are necessary for a tumor colony to grow and become invasive: angiogenesis and basement membrane degradation. Angiogenesis is the formation of new blood vessels from the endothelium of existing vasculature, in response to the metabolic demand of the tumor. Assessment of the degree of tumor angiogenesis may improve risk stratification in patients with lung cancer, especially those with early-stage disease. In addition, the strategy of blocking the mechanism of angiogenesis may prove to be an effective therapeutic alternative for patients with nonsmall cell lung cancer. Clinical trials evaluating novel antiangiogenic agents, including antibodies to vascular endothelial growth factor (VEGF) and compounds directed at the tyrosine kinase receptor, are ongoing.
References
Sep 1, 1994·Diseases of the Colon and Rectum·T J SaclaridesD B Rubin
Jan 1, 1995·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ThatcherH Anderson
Jun 1, 1997·Chest·C F Mountain
May 22, 1998·The Annals of Thoracic Surgery·K MatsuyamaN Tanigawa
May 30, 1998·The Journal of Thoracic and Cardiovascular Surgery·H ImotoK Yasumoto
Feb 4, 1999·The Annals of Thoracic Surgery·J M SiegfriedR J Landreneau
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·T L MoserS V Pizzo
Apr 17, 1999·The Journal of Biological Chemistry·M DhanabalV P Sukhatme
Aug 10, 1999·The Journal of Pathology·M DecaussinE Brambilla
Sep 22, 2001·The Annals of Thoracic Surgery·T A AloiaT A D'Amico
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Grace K Dy, Alex A Adjei
Nov 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstWaun Ki Hong
Jan 23, 2003·Microscopy Research and Technique·Noriharu ShijuboNoriyuki Sato
Citations
Jul 20, 2006·Journal of the National Cancer Institute·Cheng-Chi ChangMin-Liang Kuo
Jan 25, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chunlan TangXiangdong Zhou
Feb 4, 2011·Annals of Surgical Oncology·Shu-Hai LiLei Qi
Jan 26, 2013·PloS One·Ming-Yuh ShiauYih-Hsin Chang
Jan 15, 2014·Environmental Health Perspectives·Jun HeLing-Zhi Liu
Oct 6, 2005·Experimental Lung Research·Zia A KhanSubrata Chakrabarti
Aug 5, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Thomas E StinchcombeUNKNOWN Cancer and Leukemia Group B
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yasushi GotoTomohide Tamura
Sep 11, 2008·Revista portuguesa de pneumologia·Zafer KocakSernaz Uzunoglu
Jun 10, 2005·Clinical Lung Cancer·Anuj K Agarwala, Nasser H Hanna
Dec 7, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lair ZambonCarmen S P Lima
Oct 29, 2005·Seminars in Thoracic and Cardiovascular Surgery·Eric M Toloza, Thomas A D'Amico
Dec 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xuefei ShiYong Song
Nov 30, 2005·The American Journal of Pathology·Robert S StearmanMark W Geraci
Jun 12, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jun HeBing-Hua Jiang
Jan 25, 2013·Acta Biochimica Et Biophysica Sinica·Shuhai LiMing Lu
Aug 28, 2014·PloS One·Lei QiHui Tian
Feb 6, 2013·Journal of Thoracic Imaging·Sachiko NakanoMasatomo Mori
Nov 2, 2017·Oncotarget·Yanjun HuYunxia Wang
Dec 7, 2017·Oncotarget·Yu-Jing SunXiao-Tao Zhao