Angiogenesis in rabbit hepatic tumor after transcatheter arterial embolization

World Journal of Gastroenterology : WJG
Xiao-Feng LiaoGeng Tian

Abstract

To investigate the effect of transcatheter arterial embolization (TAE) on angiogenesis of hepatic tumor. Twenty New Zealand White rabbits were randomly divided into two groups of 10 each and VX2 carcinoma was implanted in the left medial lobes of the livers. Fourteen days later, a silicon catheter was inserted into the left hepatic artery of rabbit with VX2 hepatic tumor and infusion was performed via the hepatic artery using Lipiodol (the TAE group) or saline (the control group). Rabbits were sacrificed 7 d after treatment and tumor tissues were excised. Expression of vascular endothelial growth factor (VEGF) protein and microvessel density (MVD) of tumors were examined using immunohistochemistry. The staining intensity of VEGF was evaluated with a computer-assisted image-analyzer. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the VEGF mRNA expression of tumors. MVD was higher in the TAE group compared with the control group (28.6+/-10.6 vs 16.3+/-6.9, P<0.01). Expression of VEGF protein was enhanced after TAE. The staining intensity of VEGF in the TAE group was 0.162+/-0.018, significantly higher than in the control group (0.142+/-0.01, P<0.01). At mRNA level, VEGF165 mRNA was significantly highe...Continue Reading

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Citations

Sep 26, 2013·Journal of Vascular and Interventional Radiology : JVIR·Achilleas N ChatziioannouConstantin Tamvakopoulos
Apr 9, 2013·Journal of Vascular and Interventional Radiology : JVIR·Joshua L Weintraub, Riad Salem
Dec 2, 2005·Journal of Vascular and Interventional Radiology : JVIR·Thomas K RheeReed A Omary
Oct 17, 2008·Journal of Vascular and Interventional Radiology : JVIR·Sumeet VirmaniReed A Omary
Mar 3, 2007·International Journal of Cancer. Journal International Du Cancer·Hongchi JiangXueying Sun
Mar 22, 2014·The Korean Journal of Internal Medicine·Myeong Jun Song, Si Hyun Bae
Jun 10, 2006·Investigative Radiology·Sanjay GuptaZuxing Kan
Nov 5, 2014·Cardiovascular and Interventional Radiology·Gianluigi OrgeraMichele Rossi
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Feb 23, 2018·Cardiovascular and Interventional Radiology·Frederic DeschampsAndrew C Larson
Jul 22, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafael DuranJean-François Geschwind

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