PMID: 9421072Jan 8, 1998Paper

Angiogenesis in uterine cervical intraepithelial neoplasia and squamous cell carcinoma: an immunohistochemical study

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
B DavidsonJ Kopolovic

Abstract

Changes in vascular patterns aid in the colposcopic diagnosis of cervical neoplasia. We have studied vessels in 50 cases of normal cervix, cervical intraepithelial neoplasia (CIN I, II, III), and invasive carcinoma by two markers, Von-Willebrand factor (VWF) and ulex europaeus lectin I. With both markers, an increase in microvessel counts parallel to neoplastic progression was seen, with highest counts observed in CIN III. Average counts for ulex lectin and VWF increased from approximately 6 vessels per field in normal cervices to 15 vessels per field in CIN III. For each diagnostic group, comparable numbers of vessels were stained by both markers, with a slight preponderance of VWF in invasive carcinomas and of ulex lectin in noninvasive lesions. No correlation was found between microvessel count and human papilloma virus (HPV) by in situ hybridization. We conclude that enhanced microvessel density occurs in cervical neoplasia. The vessels are mostly blood vessels, not lymphatics. Therefore, the role of enhanced microvessel density in tumor spread remains to be proven.

Citations

Aug 26, 2003·Microvascular Research·Muhammad-Amri Abdul-KarimBadrinath Roysam
Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Ik-Jae LeeYoung-Kun Deung
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·O. Abulafia, D. M. Sherer
May 10, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TriratanachatN Jarurak
Mar 25, 2006·Molecular Medicine·Mei QiKaren J Auborn
Sep 16, 1999·American Journal of Obstetrics and Gynecology·W TjalmaP van Dam
Jun 1, 2021·PET Clinics·Katharina DendlFrederik L Giesel

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