Angiogenesis induction in Buerger's disease: a disease management double-edged sword?

Orphanet Journal of Rare Diseases
Bahare FazeliHossein Taheri

Abstract

Due to unknown aetiology of Thromboangiitis obliterans (TAO), its effectively treating is challenging. However, angiogenesis induction is one of the acceptable treatments for TAO patients. Recently, we have noticed that TAO patients who were under long-term treatment with angiogenesis-inducing medication showed considerable improvement in terms of healing chronic ulcers over the course of one to 2 years of treatment. However, some of them developed dermal gangrene despite the warming of their feet, with or without palpable pulses in the extremities, and with hair growth on the affected skin. Unfortunately, following the progression of dermal gangrene, some of these patients had to undergo amputation and limb loss.During histopathological evaluation, we detected some changes in the amputee TAO patients under long-term angiogenic medical treatment that were not present in amputee TAO patients who had not received any treatment for many years. The greatest pathological changes were observed in the microvascular of the skin, appearing as a proliferation of endothelial cells, NETosis and thrombus formation inside the vessels with proliferation of endothelial cells. The immunohistochemistry for CD31 and Ki67 as markers of vascular en...Continue Reading

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Feb 24, 2018·Central-European Journal of Immunology·Dorota Magdalena Radomska-LeśniewskaPiotr Skopiński

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Citations

Jul 9, 2021·International Angiology : a Journal of the International Union of Angiology·Bahare FazeliMustafa Hakan Zor

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Methods Mentioned

BETA
amputation
biopsies

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