Angiogenesis inhibition by a lichen compound olivetoric acid

Phytotherapy Research : PTR
Ayşe Tansu KoparalAyşen Ozdemir Türk

Abstract

Lichens have been used in folk medicine for centuries and are symbiotic organisms of fungi and algae that produce unique secondary metabolites. Olivetoric acid is one of these secondary metabolites. In the present study, the effect of olivetoric acid isolated from acetone extract of the lichen Pseudevernia furfuracea (var. ceratea) on angiogenesis was evaluated. It displayed potent anti-angiogenic activities in vitro: inhibited proliferation of rat adipose tissue endothelial cells (RATECs) and disrupted endothelial tube formation in a dose-dependent manner. Furthermore, dose-dependent depolymerization effects of olivetoric acid on F-actin stress fibers were observed. Decrease in the tube formation of RATECs by olivetoric acid might be explained by a disorganization of the actin cytoskeleton. These findings suggest that olivetoric acid is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

References

Dec 1, 1991·The Journal of Cell Biology·L L RubinJ Morales
Jan 1, 1987·Annual Review of Physiology·P A D'Amore, R W Thompson
Jul 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H FaulstichB M Jockusch
May 12, 1995·Journal of Medicinal Chemistry·G R PettitF Hogan
Jul 28, 1999·Chemistry & Biology·M Klagsbrun, M A Moses
Jan 22, 2000·Die Naturwissenschaften·S Huneck
May 9, 2000·Critical Reviews in Oncology/hematology·M Hagedorn, A Bikfalvi
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Nov 28, 2002·Phytochemistry·K Ingólfsdóttir
Sep 19, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C BézivinJ Boustie
Aug 13, 2005·Anti-cancer Drugs·Margareth MayerVirginia C L Appleyard
Nov 8, 2005·The Journal of Experimental Biology·I R AresL M Botana
Nov 1, 2006·Anti-cancer Drugs·Alessandra RussoJuan Garbarino
Nov 23, 2006·Chemical Research in Toxicology·Natalia VilariñoLuis M Botana
Apr 13, 2007·Journal of Ethnopharmacology·Hyun-Joo JungEun-Hee Park

❮ Previous
Next ❯

Citations

Apr 12, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Maonian XuSesselja Omarsdottir
Feb 16, 2021·Phytotherapy Research : PTR·Gönül Ulus
Jul 3, 2015·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Ayşe Tansu Koparal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.