Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART

International Journal of Molecular Sciences
Thajasvarie NaickerJagidesa Moodley

Abstract

Purpose of the review: This review highlights the role of angiogenesis, lymphangiogenesis, and immune markers in human immunodeficiency virus (HIV)-associated preeclamptic (PE) pregnancies in an attempt to unravel the mysteries underlying the duality of both conditions in South Africa. Recent findings: Studies demonstrate that HIV-infected pregnant women develop PE at a lower frequency than uninfected women. In contrast, women receiving highly active anti-retroviral therapy (HAART) are more inclined to develop PE, stemming from an imbalance of angiogenesis, lymphangiogenesis, and immune response. Summary: In view of the paradoxical effect of HIV infection on PE development, this study examines angiogenesis, lymphangiogenesis, and immune markers in the highly HIV endemic area of KwaZulu-Natal. We believe that HAART re-constitutes the immune response in PE, thereby predisposing women to PE development. This susceptibility is due to an imbalance in the angiogenic/lymphangiogenic/immune response as compared to normotensive pregnant women. Further large-scale studies are urgently required to investigate the effect of the duration of HAART on PE development.

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Citations

Jul 11, 2020·International Journal of Molecular Sciences·Berthold Huppertz
Jan 21, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nitalia NaidooThajasvarie Naicker
Apr 22, 2021·Archives of Gynecology and Obstetrics·Mikyle DavidThajasvarie Naicker
Jun 20, 2021·Pregnancy Hypertension·Seke Nzau Mafuika, Thajasvarie Naicker

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