Angiogenesis modulation by exogenous antioxidants

Central-European Journal of Immunology
Dorota Magdalena Radomska-LeśniewskaPiotr Skopiński

Abstract

Co-operation of the endogenous and exogenous defense system maintains redox homeostasis and is essential for health. The endogenous defense system includes enzymatic (e.g. superoxide dismutase, catalase) and non-enzymatic, low molecular-weight scavengers (e.g. glutathione, ascorbic acid). Pathogenesis of many serious diseases (e.g. cancer, ischemic heart disease) includes oxidative stress which can disturb angiogenesis, the process of formation of new blood vessels sprouting from the existing one. Antioxidants, through reduction of oxidative stress and influence on neovascularization, may modulate progress and results of therapy in those diseases where such processes play an important role. Herein the impact of exogenous antioxidants on angiogenesis and factors modulating this process is presented. Most synthetic antioxidants whose activity has been described (namely N-acetylcysteine, pentoxifylline, synthetic analogue of curcumin, synthetic analogue of epigallocatechin-3 gallate [EGCG], tripertenoids) exert an inhibitory effect on neovascularization. A similar effect was also exhibited by several natural origin antioxidants (e.g. resveratrol, EGCG), which suggests that their application in therapy might normalize excessive ang...Continue Reading

Citations

Nov 6, 2018·PloS One·Marcia Rodrigues da SilvaAdriana Lino-Dos-Santos-Franco
Aug 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Beatrice MenicacciAlessandra Mocali
Feb 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mahshid Moballegh NaseryGautam Sethi
May 21, 2020·The Journal of Pharmacy and Pharmacology·Benhur Judah CuryLuisa Mota da Silva
Nov 23, 2018·Phlebology·Devrim SaribalMehmet C Akyolcu
Aug 7, 2019·Orphanet Journal of Rare Diseases·Bahare FazeliHossein Taheri
Jan 19, 2021·International Journal of Biological Macromolecules·Wanwen ChenWenshui Xia
Jul 3, 2021·Cells·Dorota M Radomska-LeśniewskaPaweł Kamiński
Oct 8, 2021·Environmental Science and Pollution Research International·Tianyang ZhaoLin Ye

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Methods Mentioned

BETA
bronchoalveolar lavage

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