PMID: 9530779Apr 8, 1998Paper

Angiogenesis of cervix carcinoma. Contrast enhanced dynamic MRI, histologic quantification of capillary density and lymphatic system infiltration

Der Radiologe
H HawighorstG van Kaick

Abstract

It was the aim of this project to examine (i) the relationships between contrast-enhanced dynamic MR imaging derived characteristics and histologic microvessel density counts--a recognized surrogate of tumor angiogenesis--from tumors in patients with primary or recurrent cancer of the uterine cervix, and (ii) to correlate these parameters with lymphatic involvement (i.e. lymphatic channels) to assess tumor biological aggressiveness in terms of lymphatic spread. Pharmacokinetic MR imaging parameters (amplitude A, exchange rate constant k21) were derived from contrast-enhanced dynamic MR imaging in thirty-three patients with biopsy proven cancer of the uterine cervix. The pharmacokinetic MR imaging characteristics were correlated to histologic capillary density counts obtained from whole mount specimen. In addition, these data were correlated to the angiogenic activity as a marker for lymphatic system involvement. Pharmacokinetic MR imaging derived parameters (A, k21) showed a weak but significant (p < 0.05) correlation with microvessel density counts. Lymphatic involvement was more comprehensively assessed by the pharmacokinetic parameter k21 compared with histologic microvessel density, resulting in a significantly (p < 0.05) h...Continue Reading

Citations

Sep 11, 2013·Annals of Biomedical Engineering·Shengping QinKatherine W Ferrara
Dec 5, 2014·Medical Physics·Fahmi KhalifaAmy C Dwyer
Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Yoshikazu OkamotoYuji Itai
Nov 7, 1999·Radiology·H Hawighorst
Jan 30, 2010·Gynecologic Oncology·Vanessa N Harry
Oct 29, 2009·Gynecologic Oncology·Bradley J MonkDaniele A Sumner
Oct 25, 2013·Journal of Toxicologic Pathology·Makoto Tanaka, Osamu Sawamoto

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