Angiogenesis-related non-coding RNAs and gastrointestinal cancer.

Molecular Therapy Oncolytics
Zahra Sadat RazaviHamed Mirzaei

Abstract

Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.

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Citations

Jun 26, 2021·Pathology, Research and Practice·Seyed Hamed JafariMajid Nejati
Jul 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hanyu ZhangMingxing Li
Aug 23, 2021·Cancer Cell International·Rong-Quan HeGang Chen

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